Maternal and fetal cocaine- and amphetamine-regulated transcript in diabetic and non-diabetic pregnancy

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Mark P HehirFionnuala M McAuliffe

Abstract

Cocaine- and amphetamine-regulated transcript (CART) is a leptin-regulated anorectic neuropeptide. Increased levels of leptin in cord blood of diabetic mothers have previously been described. The aim of this study was to quantify maternal and fetal serum CART levels in type 1 diabetes mellitus (T1DM, n = 10) and non-diabetic pregnancy (n = 10). Matched maternal serum samples (n = 20) were obtained at 36-weeks gestation and cord samples from the umbilical vein at delivery (n = 20), CART was quantified using a competitive enzyme immunoassay. Statistical analysis was performed using Spearmans correlation and t test. There was no difference in maternal CART levels at 36-weeks gestation between T1DM (mean = 331.13 pg/ml, Standard Error of the Mean (SEM) = 114.54) and non-diabetic pregnancy (mean = 195.01 pg/ml SEM = 29.37) (p = 0.106). Fetal CART levels in the umbilical vein were similar in T1DM (mean = 199.27 pg/ml, SEM = 39.81) and non-diabetic pregnancy (mean = 149.76 pg/ml, SEM = 26.08) (p = 0.143). Maternal serum CART levels measured at 36-weeks gestation correlated with maternal BMI at booking (Spearmans ρ = 0.332) (p = 0.001) irrespective of diabetes. Serum CART can be detected in both diabetic and non-diabetic human pregnanc...Continue Reading

References

May 20, 1998·Nature·P KristensenS Hastrup
Nov 4, 2000·Biology of Reproduction·M C Henson, V D Castracane
Sep 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wing May KongStephen Bloom
Sep 26, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E EkbladF Sundler
Feb 23, 2005·Nature·Florent ElefteriouGerard Karsenty
Jul 15, 2006·The Journal of Pharmacology and Experimental Therapeutics·Aleksandra Vicentic, Douglas C Jones
Aug 17, 2006·Nutritional Neuroscience·R BelooseskyM G Ross
Aug 29, 2006·Neuropeptides·Sarika Arora, Anubhuti
Sep 23, 2006·Clinical Chemistry·Maria WeyermannDietrich Rothenbacher
Jan 11, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M D KlokM L Drent
Dec 22, 2007·Psychiatry Research·Lena BrundinAsa Petersén
Jan 24, 2008·The Journal of Clinical Endocrinology and Metabolism·Paul BechStephen R Bloom
Feb 2, 2008·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Noirin E RussellFionnuala M McAuliffe
Apr 15, 2008·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Mary F HigginsFionnuala M McAuliffe
Sep 6, 2008·American Journal of Obstetrics and Gynecology·Noirin E RussellFionnuala M McAuliffe
Sep 20, 2008·Nature Reviews. Neuroscience·G RoggeM J Kuhar
Jan 31, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Niamh CorriganFionnuala McAuliffe
Dec 26, 2009·Current Diabetes Reviews·Mary Higgins, Fionnuala Mc Auliffe

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Citations

Feb 20, 2020·International Journal of Molecular Sciences·Fionán DonohoeDonal J Brennan

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