Maternal and fetal ethanol pharmacokinetics and cardiovascular responses in near-term pregnant sheep

Canadian Journal of Physiology and Pharmacology
M E CummingD S Sitar

Abstract

The disposition and cardiovascular effects of ethanol were studied in near-term pregnant sheep and their fetuses after intravenous infusions either to the mother or the fetus. Placental transfer of ethanol from mother to fetus was rapid, but transfer from the fetal to maternal circulation was impaired when ethanol was administered directly to the fetus. Plasma clearance of ethanol was similar from the mother and fetus in utero. In the maternal infusion experiments, both maternal and fetal heart rate increased with plasma ethanol concentration. However, in the fetal infusion experiments, both maternal and fetal heart rate increased with plasma ethanol concentration. However, in the fetal infusion experiments, fetal heart rate was inversely related to plasma ethanol concentrations while maternal mean arterial blood pressure increased with maternal plasma ethanol concentration. Further studies in neonatal lambs are needed to determine if ethanol has adverse effects on hemodynamics when the neonate is separated from its protective intrauterine environment.

References

Sep 1, 1990·British Journal of Pharmacology·C J ChandlerD S Sitar
Dec 1, 1987·American Journal of Obstetrics and Gynecology·B RichardsonJ F Brien
Jul 1, 1987·American Journal of Obstetrics and Gynecology·J F BrienJ Patrick
Apr 1, 1991·Toxicology and Applied Pharmacology·C J ChandlerD S Sitar
Oct 10, 2018·American Journal of Physiology. Endocrinology and Metabolism·Jacquelyn M WalejkoMaureen Keller-Wood
Jan 1, 1989·Annals of the New York Academy of Sciences·H H Szeto
Aug 1, 1989·Alcoholism, Clinical and Experimental Research·A Zorzano, E Herrera

Related Concepts

Ethanol
Fetal Structures
Entire Fetus
Ethanol Measurement
Uterus
Cardiovascular System
Dall Sheep
Adverse Effects
Fetal Heart
Sheep antigen

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