Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: a population-based Swedish cohort study

American Journal of Medical Genetics. Part a
Sven CnattingiusPaul Lichtenstein

Abstract

There is accumulated evidence for genetic influences on preeclampsia. However, no study has been able to separate the effects of maternal and fetal genetic factors from environmental factors, and there are still uncertainties about the origin and magnitude of the genetic effects. We used the population-based Swedish Birth and Multi-Generation Registries to identify a cohort of women who gave birth from 1987 through 1997. In order to separate the genetic and environmental contributions to preeclampsia, we analyzed pregnancy outcomes from families joined by full siblings. We included information from 244,564 sibling pairs (62,236 sister pairs, 63,288 brother pairs, and 119,040 sister-brother pairs), who had 701,488 pregnancies. We found that 35% of the variance in liability of preeclampsia was attributable to maternal genetic effects, 20% to fetal genetic effects (with similar contribution of maternal and paternal genetic effects), 13% to the couple effect, less than 1% to shared sibling environment, and 32% to unmeasured factors. Among women and men without a history of preeclampsia, partner change reduced the risk of preeclampsia (odds ratio, 0.6; 95 percent confidence interval, 0.4-0.9). Genetic factors account for more than h...Continue Reading

References

Jul 10, 1991·JAMA : the Journal of the American Medical Association·B EskenaziS Sidney
Sep 1, 1990·British Journal of Obstetrics and Gynaecology·R ArngrimssonG Snaedal
Apr 1, 1990·Tissue Antigens·D C KilpatrickW A Liston
Nov 1, 1989·European Journal of Obstetrics, Gynecology, and Reproductive Biology·D S SeidmanR Gale
Sep 1, 1980·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J G Feeney, J S Scott
Mar 1, 1994·Scandinavian Journal of Social Medicine·F E Skjeldestad
May 1, 1994·American Journal of Obstetrics and Gynecology·J D Forrest
May 1, 1993·Journal of Reproductive Immunology·P Y RobillardE Papiernik
Aug 1, 1996·Obstetrics and Gynecology·C J BergM Tucker
May 1, 1996·Epidemiology·L S TrupinB Eskenazi
Jan 22, 1998·Acta Obstetricia Et Gynecologica Scandinavica·U Høgberg, N Larsson
Mar 20, 1998·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·R B Cincotta, S P Brennecke
Jun 6, 1998·BMJ : British Medical Journal·R T LieL M Irgens
Nov 20, 1998·American Journal of Obstetrics and Gynecology·G A Dekker, B M Sibai
Jul 21, 1999·European Journal of Obstetrics, Gynecology, and Reproductive Biology·P Y RobillardT C Hulsey
Sep 1, 1999·Epidemiology·I MogrenH Stenlund
Jan 7, 2000·American Journal of Epidemiology·D K Li, S Wi
Aug 2, 2000·Human Reproduction·I de Luca BrunoriA R Genazzani
Dec 16, 2000·BJOG : an International Journal of Obstetrics and Gynaecology·R A OdegårdR Austgulen
Mar 22, 2001·The New England Journal of Medicine·M S EsplinM W Varner
Apr 11, 2001·Lancet·A Lucassen, M Parker
Jan 5, 2002·The New England Journal of Medicine·Rolv SkjaervenRolv T Lie
Aug 24, 2002·American Journal of Obstetrics and Gynecology·Dorothea MostelloTerry Leet
Oct 17, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Augusta M A LachmeijerReynir Arngrímsson

❮ Previous
Next ❯

Citations

Apr 10, 2013·Trends in Genetics : TIG·Elizabeth A BrownPardis C Sabeti
Mar 26, 2010·Psychological Medicine·T FrisellN Långström
Feb 7, 2013·European Journal of Human Genetics : EJHG·Kerttu K MajanderHannele Laivuori
Nov 8, 2012·International Journal of Epidemiology·Eleonora Staines-UriasJuan P Casas
Nov 24, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Yves GiguèreJean-Claude Forest
Jan 11, 2008·Journal of Perinatal Medicine·Sabine MützeWerner Rath
Aug 15, 2014·BMJ : British Medical Journal·Anna Sara ObergBrian T Bateman
Jul 6, 2014·Journal of Pregnancy·Kjell HaramBálint Nagy
May 15, 2013·Medical Hypotheses·Sonia T ChelbiDaniel Vaiman
Oct 31, 2012·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ulrich Abildgaard, Ketil Heimdal
Sep 25, 2012·Molecular Immunology·David C Kilpatrick
May 26, 2012·Annales de cardiologie et d'angéiologie·L DoridotD Vaiman
Mar 14, 2008·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·Sandra A FoundsYvette P Conley
Apr 1, 2011·Pregnancy Hypertension·Serena BertozziDiego Marchesoni
Apr 20, 2010·Néphrologie & thérapeutique·Michel Beaufils
Jul 7, 2009·Journal of Reproductive Immunology·Virginie RigourdDaniel Vaiman
Mar 8, 2016·Database : the Journal of Biological Databases and Curation·Alper UzunJames F Padbury
Jan 8, 2008·Molecular and Cellular Endocrinology·S T Chelbi, D Vaiman
May 12, 2007·Journal of Reproductive Immunology·Gus Dekker, Pierre-Yves Robillard
Aug 19, 2015·Immunological Reviews·Ashley Moffett, Francesco Colucci
Aug 10, 2015·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Masoumeh GhasemiMajid Shahbazi
Aug 15, 2014·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Helen L BarrettLeonie K Callaway
Jan 10, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·L M ProcopciucF Stamatian
Dec 23, 2010·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Lyle G BestCindy M Anderson
Sep 26, 2012·Chronobiology International·Diana E Ayala, Ramón C Hermida
Sep 11, 2007·American Journal of Obstetrics and Gynecology·Jae-Yoon ShimAhm Kim
Mar 13, 2010·American Journal of Obstetrics and Gynecology·Sindhu K SrinivasMichal A Elovitz
Jul 5, 2011·American Journal of Obstetrics and Gynecology·Anna-Karin WikströmSven Cnattingius
Feb 7, 2006·American Journal of Obstetrics and Gynecology·Anna C SvenssonPaul Lichtenstein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.