Maternal and fetal insulin-like growth factors and their binding proteins in the second and third trimesters of human pregnancy

Human Reproduction
K LangfordJ P Miell

Abstract

The insulin-like growth factors (IGFs) are mitogenic polypeptides which circulate bound to a series of at least six binding proteins (IGFBPs). An increasing body of evidence supports a major role for the IGF in the control of human fetal growth although normal values in the human fetal circulation have not been established. In order to provide an accurate reflection of fetal IGFs and IGFBPs in utero, we have sampled fetal blood direct from the umbilical cord at 18-38 weeks of gestation using the technique of cordocentesis. We have measured IGF-I, IGF-II and IGFBP 1-3 in 91 fetuses in order to establish concentrations for these parameters in the second and third trimesters of human pregnancy.

Citations

Mar 3, 2007·Angiogenesis·Jing Chen, Lois E H Smith
Nov 3, 2009·Documenta Ophthalmologica. Advances in Ophthalmology·Elsa Kermorvant-DucheminSylvain Chemtob
Feb 23, 2013·Seminars in Fetal & Neonatal Medicine·Anna-Lena HårdAnn Hellström
Aug 14, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Anders Juul
Jul 14, 2009·Journal of Perinatal Medicine·Maria Dalva Barbosa Baker MéioAníbal Sanchez Moura
Feb 16, 2011·Pediatrics·Gil BinenbaumUNKNOWN Premature Infants in Need of Transfusion Study Group
Jun 26, 2001·Clinical and Experimental Immunology·M S RonkainenUNKNOWN Finnish Trigr Study Group
Jan 22, 2010·Journal of Genetics·Yureeda QaziBalamurali K Ambati
Apr 18, 2009·Seminars in Ophthalmology·Gena HeidaryLois E Smith
May 31, 2013·Clinics in Perinatology·Lois E SmithAnn Hellström
Oct 16, 2009·Early Human Development·C Romagnoli
Jun 4, 2011·Journal of Pediatric Ophthalmology and Strabismus·Ferhat CekmezSerdar Umit Sarici
Apr 27, 2013·Acta Ophthalmologica·Giacomo CavallaroFabio Mosca
May 26, 2011·Clinical Endocrinology·Deborah L RowePaul L Hofman
Oct 8, 2005·Biology of the Neonate·Lois E H Smith
Oct 5, 2011·Neonatology·José Carlos RiveraSylvain Chemtob
Jul 13, 1999·Human Reproduction·R P HolmesP W Soothill
Aug 31, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S-T Joseph HuangLinda C Giudice
Feb 4, 2011·The Journal of Clinical Endocrinology and Metabolism·Ingrid Hansen-PuppDavid Ley
Nov 13, 2008·The Journal of Clinical Endocrinology and Metabolism·Ingrid Hansen-PuppDavid Ley
Aug 26, 2020·Ophthalmic Epidemiology·Alejandra G de Alba CampomanesGil Binenbaum
Nov 26, 2018·The Journal of Pediatrics·David LeyUNKNOWN study team

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.