PMID: 1079930Jun 1, 1975Paper

Maternal and fetal outcome associated with hemoglobin E trait and hemoglobin E disease

Obstetrics and Gynecology
H C Ong


A study of 20 patients with hemoglobin E trait abnormality and 8 patients with hemoglobin E disease in pregnancy is presented. The hematologic abnormality in HbE hemoglobinopathy is mild though hemoglobin values are significantly lower than in HbA patients. Fetal wastage is no increased and the salvage rate is high (live births over 95 per cent). The mean birthweight of the baby in HbE patients is significantly lower than in HbA patients, but the incidence of prematurity is not significantly increased in HbE patients. Blood loss at delivery is not markedly affected by hemoglobin type. The incidences of postpartum hemorrhage, preeclampsia, and malaria are not significantly increased in HbE patients; the reason for the significant increase in incidence of abruptio placentae in HbE is not known. No maternal deaths or congenital fetal abnormalities were recorded. It is concluded that the course of pregnancy in HbE trait abnormality and HbE disease is relatively benign.


Aug 13, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S TangjitgamolS Jesadapatarakul
Feb 1, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·S-Y RimH-S Choi
Apr 30, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Walairat KemthongTheera Tongsong
Jul 28, 2016·Maternal and Child Health Journal·Supatra SirichotiyakulTheera Tongsong
Aug 1, 1987·American Journal of Hematology·N A Lachant

Related Concepts

Abortion, Tubal
Abruptio Placentae
Fetal Mummification
Abnormal Hemoglobins
Immediate Postpartum Hemorrhage
Postneonatal Mortality
Neonatal Prematurity

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