Abstract
Pregnancies in women with Loeys-Dietz syndrome (LDS) are rare and are typically documented in case reports only. Early reports suggested high rates of maternal complications during pregnancy and the puerperium, including aortic dissection and uterine rupture, but information on fetal outcomes was very limited. A retrospective cohort study. Eight specialist UK centres. Pregnant women with LDS. Data was collated on cardiac, obstetric, and neonatal outcomes. Maternal and perinatal outcomes in pregnancies complicated by LDS. Twenty pregnancies in 13 women with LDS were identified. There was one miscarriage, one termination of pregnancy, and 18 livebirths. In eight women the diagnosis was known prior to pregnancy but only one woman had preconception counselling. In four women the diagnosis was made during pregnancy through positive genotyping, and the other was diagnosed following delivery. Five women had a family history of aortic dissection. There were no aortic dissections in our cohort during pregnancy or postpartum. Obstetric complications were common, including postpartum haemorrhage (33%) and preterm delivery (50%). In all, 14/18 (78%) of deliveries were by elective caesarean section, at a median gestational age at delivery o...Continue Reading
References
Nov 7, 1987·British Medical Journal·S C RobsonS Hunter
May 12, 1994·The New England Journal of Medicine·J ShoresR E Pyeritz
Jan 5, 2000·Heart·N SutariaD Northridge
Feb 1, 2005·European Heart Journal·Lilian J MeijboomBarbara J M Mulder
Feb 26, 2005·Nature Genetics·Bart L LoeysHarry C Dietz
Aug 25, 2006·The New England Journal of Medicine·Bart L LoeysHarry C Dietz
Oct 2, 2008·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·J J J AalbertsJ P van Tintelen
Jun 23, 2009·Journal of Medical Genetics·V Tran-FaduluD M Milewicz
Sep 29, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·M JonssonS Nordén-Lindeberg
Dec 10, 2009·Circulation·David AttiasGuillaume Jondeau
Aug 30, 2011·European Heart Journal·Vera Regitz-ZagrosekUNKNOWN ESC Committee for Practice Guidelines
Dec 15, 2011·Journal of Medical Genetics·Ingrid M B H van de LaarMarja W Wessels
Mar 3, 2012·BMJ : British Medical Journal·Elaine M BoyleMaria A Quigley
Mar 1, 2014·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Gretchen MacCarrickHarry C Dietz
Feb 26, 2016·BMJ : British Medical Journal·Matthew CauldwellMichael Gatzoulis
Apr 22, 2016·International Journal of Cardiology·Matthew CauldwellLorna Swan
Apr 30, 2016·American Journal of Medical Genetics. Part a·Alan C BravermanNicholas T Kouchoukos
Aug 16, 2016·International Journal of Cardiology·Matthew CauldwellMark R Johnson
Oct 26, 2016·International Journal of Cardiology·Charlotte J FriseLucy Mackillop
Nov 24, 2016·Circulation. Cardiovascular Genetics·Guillaume JondeauUNKNOWN Montalcino Aortic Consortium
Jan 14, 2017·Circulation·Mary M CanobbioUNKNOWN American Heart Association Council on Cardiovascular and Stroke Nursing; Council on Clinical Cardiology; Council on Cardiova
Mar 23, 2017·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Julia GeigerBrigitte Stiller
Apr 6, 2017·International Journal of Cardiology·M CauldwellM R Johnson
Jun 13, 2017·A & a Case Reports·Ravish KapoorEmad B Mossad
Dec 23, 2017·Annals of Cardiothoracic Surgery·Sorel Goland, Uri Elkayam
May 15, 2018·PloS One·Marjolijn RenardLynn Y Sakai
Aug 31, 2018·European Heart Journal·Vera Regitz-ZagrosekUNKNOWN ESC Scientific Document Group
Sep 23, 2018·Heart·Matthew CauldwellMark R Johnson