Maternal and fetal outcomes in pregnancies complicated by the inherited aortopathy Loeys-Dietz syndrome

BJOG : an International Journal of Obstetrics and Gynaecology
Matthew CauldwellM R Johnson

Abstract

Pregnancies in women with Loeys-Dietz syndrome (LDS) are rare and are typically documented in case reports only. Early reports suggested high rates of maternal complications during pregnancy and the puerperium, including aortic dissection and uterine rupture, but information on fetal outcomes was very limited. A retrospective cohort study. Eight specialist UK centres. Pregnant women with LDS. Data was collated on cardiac, obstetric, and neonatal outcomes. Maternal and perinatal outcomes in pregnancies complicated by LDS. Twenty pregnancies in 13 women with LDS were identified. There was one miscarriage, one termination of pregnancy, and 18 livebirths. In eight women the diagnosis was known prior to pregnancy but only one woman had preconception counselling. In four women the diagnosis was made during pregnancy through positive genotyping, and the other was diagnosed following delivery. Five women had a family history of aortic dissection. There were no aortic dissections in our cohort during pregnancy or postpartum. Obstetric complications were common, including postpartum haemorrhage (33%) and preterm delivery (50%). In all, 14/18 (78%) of deliveries were by elective caesarean section, at a median gestational age at delivery o...Continue Reading

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Citations

Feb 6, 2020·Prenatal Diagnosis·Anne H MardyMary E Norton

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