PMID: 17606958Jul 4, 2007Paper

Maternal and fetal outcomes in pregnant women with acute hepatitis E virus infection

Annals of Internal Medicine
Sharda PatraShiv Kumar Sarin

Abstract

Hepatitis E virus (HEV) infection is known to cause severe liver disease in pregnant women. It is unclear whether obstetric and fetal outcomes are worse in pregnant women with HEV infection than in women with other forms of viral hepatitis. To compare maternal, obstetric, and fetal outcomes in pregnant women with acute viral hepatitis caused by HEV and other hepatitis viruses. Observational cohort. Tertiary care hospital, New Delhi, India. 220 consecutive pregnant women presenting with jaundice caused by acute viral hepatitis. Maternal mortality and medical complications, obstetric complications, deliveries, and fetal outcomes. Infection with HEV caused acute viral hepatitis in 60% of included women. Fulminant hepatic failure was more common (relative risk, 2.7 [95% CI, 1.7 to 4.2]; P = 0.001) and maternal mortality was greater (relative risk, 6.0 [CI, 2.7 to 13.3]; P < 0.001) in HEV-infected women than in non-HEV-infected women. Women with HEV infection were more likely than those with other forms of viral hepatitis to have obstetric complications (relative risk, 4.1 [CI, 1.7 to 10.2] for antepartum hemorrhage and 1.9 [CI, 1.3 to 2.7] for intrauterine fetal death; P < 0.001 for both) and poor fetal outcomes (relative risk, 1.2...Continue Reading

Citations

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