Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy.

PloS One
Mary F HigginsF M McAuliffe

Abstract

Placental growth hormone (PGH) is a major growth hormone in pregnancy and acts with Insulin Like Growth Factor I (IGF-I) and Insulin Like Growth Hormone Binding Protein 3 (IGFBP3). The aim of this study was to investigate PGH, IGF-I and IGFBP3 in non-diabetic (ND) compared to Type 1 Diabetic (T1DM) pregnancies. This is a prospective study. Maternal samples were obtained from 25 ND and 25 T1DM mothers at 36 weeks gestation. Cord blood was obtained after delivery. PGH, IGF-I and IGFBP3 were measured using ELISA. There was no difference in delivery type, gender of infants or birth weight between groups. In T1DM, maternal PGH significantly correlated with ultrasound estimated fetal weight (r = 0.4, p = 0.02), birth weight (r = 0.51, p<0.05) and birth weight centile (r = 0.41, p = 0.03) PGH did not correlate with HbA1c. Maternal IGF-I was lower in T1DM (p = 0.03). Maternal and fetal serum IGFBP3 was higher in T1DM. Maternal third trimester T1DM serum had a significant band at 16 kD on western blot, which was not present in ND. Maternal T1DM PGH correlated with both antenatal fetal weight and birth weight, suggesting a significant role for PGH in growth in diabetic pregnancy. IGFBP3 is significantly increased in maternal and fetal se...Continue Reading

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Citations

Jul 12, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Hüseyin CengizHediye Dağdeviren
Nov 22, 2015·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Lene RingholmElisabeth R Mathiesen
Apr 3, 2019·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Umit GorkemEmine Arslan
Apr 17, 2018·Endocrinology·Shutan LiaoJo K Perry
Aug 15, 2017·Biomedical Reports·Alexandros VelegrakisStavros Sifakis
Sep 15, 2018·Frontiers in Endocrinology·Huihua Ding, Tianfu Wu
Aug 16, 2018·Frontiers in Endocrinology·Sofia NahavandiElif I Ekinci

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Methods Mentioned

BETA
ELISA
enzyme linked immunosorbent assay
SGA
enzyme-linked immunoassay
X-ray

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