Jan 1, 1975

Maternal and fetal plasma levels of free corticosteroids in pathological deliveries

Journal of Perinatal Medicine
J Schmid


Does intrauterine acidosis induce increased steroid secretion? The concentration of free steroids (CS) increases in both fetal and maternal plasma during labor and delivery. Fetal levels are higher after vaginal than after cesarean section. These differences may indicate an important role of the fetal adrenal gland in the induction of labor or they may reflect merely the fetal response to the stress of delivery. During incrased intrauterine stress steroid secretion is increased as shown here. We examined 41 mothers and their infants during pathological labor. Pathology was assessed from fetal acidosis and/or a clinically obstetric disease of the mother or fetus. The 41 cases included 9 cesarean sections, 8 forceps deliveries; 24 spontaneous deliveries of which 7 were premature. At the time of delivery the pH and CS level were determined in maternal and umbilical vessels in all cases. During spontaneous labor blood samples were also taken during the different stages of labour. A competetive protein binding assay with transcortin without fractionation of the steroids was used. Progesteron was determined by the same assay. The level of this hormone, however, remains unchanged and hence any changes reflect changes in CS. The levels...Continue Reading

Mentioned in this Paper

Spontaneous Onset of Labor
Protein Binding
Entire Fetus
Venous Blood Substance
Umbilicus (Anatomy)
Postcesarean Section
Fetal Distress
Portion of Venous Blood
Corticosteroids, topical for treatment of hemorrhoids and anal fissures
Process of Secretion

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