Maternal and fetal tryptophan metabolism in gestating rats: effects of intrauterine growth restriction

Amino Acids
Mitsue SanoDominique Darmaun

Abstract

L-Tryptophan (L-Trp) is a precursor for serotonin (5-HT) and nicotinamide adenine dinucleotide (NAD) synthesis. Both 5-HT and NAD may impact energy metabolism during gestation given that recent studies have demonstrated that increased 5-HT production is crucial for increasing maternal insulin secretion, and that sirtuin, an NAD(+)-dependent protein deacetylase, regulates endocrine signaling. Infants born with intrauterine growth restriction (IUGR) are at a higher risk of metabolic disease once they reach adulthood. IUGR is associated with altered maternal-fetal amino acid transfer. Whether IUGR affects L-Trp metabolism in mother and fetus has not been fully elucidated. Recently, we developed an analytical method using stable isotope-labeled L-Trp to explore the metabolism of L-Trp and its main metabolites, L-kynurenine (L-Kyn), 5-HT and quinolinic acid (QA). In this study, dams submitted to dietary protein restriction throughout gestation received intravenous infusions of stable isotope-labeled (15)N2-L-Trp to determine whether L-Trp metabolism is affected by IUGR. Samples were obtained from maternal, fetal and umbilical vein plasma, as well as the amniotic fluid (AF), placenta and liver of the mother and the fetus after isotop...Continue Reading

References

Aug 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·O Greengard, H K Dewey
Jul 15, 1983·Neuroscience Letters·R Schwarcz, C Köhler
Dec 22, 1999·American Journal of Obstetrics and Gynecology·T NichollsD W Walker
Nov 10, 2001·The Journal of Clinical Endocrinology and Metabolism·C L PaoliniF C Battaglia
Dec 12, 2001·Molecular and Cellular Endocrinology·T J RoseboomO P Bleker
Jan 26, 2002·British Medical Bulletin·C E Bertram, M A Hanson
Jan 24, 2003·The American Journal of Clinical Nutrition·Hidemi OkamotoKatsumi Shibata
May 18, 2005·Journal of Nutritional Science and Vitaminology·Tsutomu FtukijwatariKatsumi Shibata
May 11, 2006·Trends in Endocrinology and Metabolism : TEM·Tianle YangAnthony A Sauve
Jun 29, 2010·Nature Medicine·Hail KimMichael S German
Nov 19, 2010·Clinical Nephrology·P KoenigD Fuchs
Jan 5, 2011·Frontiers in Bioscience (Scholar Edition)·Kang YaoGuoyao Wu
Apr 23, 2011·Nature·Alexandre BonninPat Levitt
Jun 4, 2011·Current Biology : CB·Susanna CampesanFlaviano Giorgini
Dec 20, 2012·International Journal of Nephrology·Euming Chong, Ihor V Yosypiv
Jan 11, 2013·Journal of Pregnancy·Susanne Lager, Theresa L Powell
Nov 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mica Ohara-ImaizumiShinya Nagamatsu

❮ Previous
Next ❯

Citations

Jul 25, 2017·International Journal of Molecular Sciences·Kang XuYulong Yin
Aug 23, 2020·International Journal of Molecular Sciences·Sabrina I HanswijkJudith R Homberg
Oct 18, 2020·International Journal of Molecular Sciences·Cilia AbadFrantisek Staud
May 23, 2019·Developmental Neuroscience·Francesca M NotarangeloRobert Schwarcz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
A M Di GiulioI Cetin
Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica
T Deguchi
Biochemical and Biophysical Research Communications
A J ANDREOLIO HAYAISHI
© 2021 Meta ULC. All rights reserved