Maternal and fetoplacental hypoxia do not alter circulating angiogenic growth effectors during human pregnancy

Biology of Reproduction
S ZamudioN P Illsley

Abstract

One causal model of preeclampsia (PE) postulates that placental hypoxia alters the production of angiogenic growth effectors (AGEs), causing an imbalance leading to maternal endothelial cell dysfunction. We tested this model using the natural experiment of high-altitude (HA) residence. We hypothesized that in HA pregnancies 1) circulating soluble fms-like tyrosine kinase 1 (sFlt-1) is increased and placental growth factor (PlGF) decreased, and 2) AGE concentrations correlate with measures of hypoxia. A cross-sectional study of healthy pregnancies at low altitude (LA) (400 m) versus HA (3600 m) compared normal (n = 80 at HA, n = 90 at LA) and PE pregnancies (n = 20 PE at HA, n = 19 PE at LA). Blood was collected using standard serum separation and, in parallel, by a method designed to inhibit platelet activation. AGEs were measured by enzyme-linked immunosorbent assays. AGEs did not differ between altitudes in normal or PE pregnancies. AGE concentrations were unrelated to measures of maternal or fetal hypoxia. PlGF was lower and sFlt-1 higher in PE, but overlapped considerably with the range observed in normal samples. PlGF correlated with placental mass in both normal and PE pregnancies. The contribution of peripheral cells to ...Continue Reading

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Citations

Feb 25, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Carolin KienastAnnegret Geipel
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May 3, 2018·Physiological Reviews·Charles A DucsayLubo Zhang
Mar 11, 2020·Frontiers in Endocrinology·Jiri Pavlacky, Jan Polak
Dec 16, 2018·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Berthold Huppertz
Dec 31, 2020·Human Reproduction Update·Arthur ColsonAmanda N Sferruzzi-Perri
Jul 20, 2021·Frontiers in Physiology·Christopher A WakerThomas L Brown

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Methods Mentioned

BETA
urine collection
enzyme-linked immunosorbent assay
blood collection

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