Maternal and gestational influences on childhood blood pressure.

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Bonita Falkner

Abstract

Exposures that contribute to a sub-optimal intrauterine environment can have an effect on the developing fetus. Impaired fetal growth that results in low birth weight is an established risk factor for cardio-metabolic disorders later in life. Recent epidemiologic and prospective cohort studies that include the maternal and gestational period have identified maternal and gestational conditions that confer increased risk for subsequent cardio-metabolic disorders in the absence of low birth weight. Maternal pre-conception health status, including chronic obesity and type 2 diabetes, increase risk for childhood obesity and obesity-related higher blood pressure (BP) in child offspring. Maternal gestational exposures, including gestational diabetes, gestational hypertension, and preeclampsia, are associated with higher BP in offspring. Other maternal exposures such as cigarette smoke and air pollution also increase risk for higher BP in child offspring. Recent, but limited, data indicate that assisted reproductive technologies can be associated with hypertension in childhood, despite otherwise normal gestation and healthy newborn. Gestational exposures associated with higher BP in childhood can be related to familial lifestyle factor...Continue Reading

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Citations

Sep 13, 2019·BMC Public Health·Marília Cruz GuttierIná S Santos
Dec 5, 2019·Global Pediatric Health·Hugo Razini OliveiraKamila Caroline Minosso
Sep 8, 2020·Current Hypertension Reports·Carissa M Baker Smith, Amy Peterson
Feb 14, 2021·The Canadian Journal of Cardiology·Bonita Falkner, Samuel Gidding
Jul 18, 2021·Environmental Research·Delphine Rousseau-RalliardPascale Chavatte-Palmer
Jan 19, 2022·Paediatric and Perinatal Epidemiology·Szimonetta EitmannErika Pétervári

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