Maternal and infant death after probable vertical transmission of chikungunya virus in Brazil - case report

BMC Infectious Diseases
Rhaquel de Morais Alves Barbosa OliveiraLuciano Pamplona de Góes Cavalcanti

Abstract

Chikungunya virus infection in neonates is relatively rare and can lead to death. We report the occurrence of the first death of a mother and child after probable vertical transmission of chikungunya virus in Brazil. A 28-year-old pregnant woman with hypertension presented with symptoms compatible with an arboviral disease at 34 weeks' gestation. She developed preeclampsia with severe respiratory failure which resulted in the emergency cesarean section, and the patient died 12 days after the onset of symptoms. The pre-term newborn weighed 2535 g, with an Apgar score of 4/8. He was referred to the neonatal ICU with neutrophilia and thrombocytopenia, several seizure episodes, and hemorrhagic disorders, which resulted in death. Chikungunya IgM antibody was detected in the cerebrospinal fluid. We present the first documented maternal and neonatal death in Brazil after probable chikungunya infection during pregnancy.

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Citations

Mar 22, 2019·Journal of Virology·Angelica Cifuentes KottkampKenneth A Stapleford
Aug 9, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Shirlene Telmos Silva de LimaFabio Miyajima
Oct 28, 2020·Indian Journal of Dermatology, Venereology and Leprology·Sahana M Srinivas, G C Marlursiddappa Pradeep
Apr 24, 2021·PloS One·Fátima Cristiane Pinho de Almeida Di Maio FerreiraPatrícia Brasil
Jul 3, 2021·Tropical Medicine and Infectious Disease·Elizabeth M TraverseKelli L Barr
Jul 16, 2021·Frontiers in Microbiology·UNKNOWN Translational Research Consortia (TRC) for Chikungunya Virus in India
Sep 22, 2021·Virology Journal·Abdulrahim R HakamiAli Essa Asiry

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Methods Mentioned

BETA
PCR

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