Aug 30, 2008

Maternal and neonatal interleukin-1 receptor antagonist genotype and pregnancy outcome in a population with a high rate of pre-term birth

American Journal of Reproductive Immunology : AJRI
José Humberto Belmino ChavesSteven S Witkin

Abstract

We evaluated associations between a length polymorphism in intron 2 of the gene coding for IL-1ra (gene symbol IL1RN) and pregnancy outcome in a population with a high rate of preterm birth. Subjects were pregnant women in Maceio, Brazil and their newborns. DNA was tested for IL1RN genotypes and alleles by gene amplification using primer pairs that spanned the polymorphic region. Every subject completed a detailed questionnaire. The frequency of allele 2 (IL1RN*2) carriage was elevated in mothers with a spontaneous preterm birth (SPTB) in the current pregnancy (P = 0.02) and also with a prior preterm delivery (P = .01). Both SPTB with intact membranes (P = 0.01) and SPTB preceded by pre-term premature rupture of membranes (P = .03) were associated with ILlRN*2 carriage. A previous fetal demise was more than twice as prevalent in mothers positive for two copies of IL1RN*2. Maternal carriage of ILlRN*2 increases susceptibility to inflammation-triggered spontaneous pre-term birth.

  • References15
  • Citations12

References

  • References15
  • Citations12

Citations

Mentioned in this Paper

Tissue Membrane
Gene Amplification
IL1RN gene
IL1RN wt Allele
Term Birth
Interleukin-1 Receptor Antagonist [EPC]
Premature Birth
Oligonucleotide Primers
Interleukin 1 Receptor Antagonist Protein
Fetal Membranes, Premature Rupture

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