Maternal and neonatal outcomes of pregnancy in women with chronic hypertension: a retrospective analysis of a national register

Acta Obstetricia Et Gynecologica Scandinavica
Kim BroekhuijsenMaureen T M Franssen

Abstract

Pregnancies complicated by chronic hypertension are at increased risk of adverse pregnancy outcomes. To assess whether planned early delivery might prevent some of these adverse outcomes, we studied maternal and neonatal outcomes of pregnancy in women with chronic hypertension, including gestational-age-specific outcomes. We performed a retrospective, population-based cohort study, using data from the Netherlands Perinatal Register. We included women with chronic hypertension and normotensive controls who delivered a singleton without congenital anomalies in 2002-2007. We calculated crude and adjusted odds ratios (OR) with 95% CI, compared delivery and ongoing pregnancy using moving averages, and used multiple Cox regression to adjust for differences in baseline characteristics and to examine adverse neonatal outcomes across subgroups of hypertensive disorder. Main outcome measures were composite adverse maternal and neonatal outcomes. We included 3457 (0.3%) women with chronic hypertension and 984 932 normotensive controls. Women with chronic hypertension had adverse maternal outcomes more often (28.7% vs. 6.6%, adjusted OR 5.7, 95% CI 5.3-6.2). Their offspring had an increased rate of neonatal morbidity (17.4% vs. 13.2%, adju...Continue Reading

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Citations

Oct 17, 2015·International Journal of Molecular Sciences·Maria Carolina Gongora, Nanette K Wenger
Oct 30, 2016·Acta Obstetricia Et Gynecologica Scandinavica·Eva F ZwertbroekUNKNOWN HYPITAT-II Study Group
Aug 11, 2018·Obstetrics and Gynecology·Maya RamUNKNOWN Diabetes, Obesity and Hypertension in Pregnancy Research Network (DOH-NET) and the Southern Ontario Obstetrical Network (SOO
Sep 28, 2018·Current Nutrition Reports·Lydi-Anne Vézina-ImTom Baranowski
Apr 17, 2021·Human Reproduction·M PontesilliR C Painter
Apr 7, 2021·American Journal of Obstetrics and Gynecology·Sukainah Y Al KhalafAli S Khashan
May 23, 2021·Pregnancy Hypertension·Kristina Baker SoleKatariina Laine
Apr 20, 2021·Journal of the American Heart Association·Sukainah Y Al KhalafAli S Khashan

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