Anorectal malformations (ARM) are major congenital malformations that usually require a multitude of surgical procedures at a very early age and have a large impact on the lives of patients and their parents. The causes of ARM are still largely unknown, but they are assumed to have a multifactorial etiology. A few studies focused on environmental risk factors, but evidence is still scarce. In this Dutch case-control study (1996-2008), we investigated the role of maternal and paternal risk factors in the etiology of ARM. Parents of 85 ARM cases and 650 controls filled in a questionnaire. Controls were children treated with ear ventilation tubes. A higher occurrence of fever during the first trimester of pregnancy was found for case mothers compared to control mothers (odds ratio [OR], 5.1; 95% Confidence Interval [CI], 0.9, 28.1). Maternal occupational exposure to industrial cleaning agents and solvents increased the risk of ARM three times (OR, 2.9; 95% CI, 0.9, 9.3). Overweight (Body Mass Index [BMI] > or = 25 kg/m(2)) before pregnancy also seemed to be associated with ARM (OR, 1.8; 95% CI, 1.1, 2.8), as well as maternal multivitamin use during pregnancy (OR, 1.6; 95% CI, 1.0, 2.7), paternal smoking (OR, 1.8; 95% CI, 1.1, 2.9)...Continue Reading
Impaired distribution of retinoic acid receptors in the hindgut-tailgut region of murine embryos with anorectal malformations
Maternal exposure to lorazepam and anal atresia in newborns: results from a hypothesis-generating study of benzodiazepines and malformations
Maternal and paternal risk factors for cryptorchidism and hypospadias: a case-control study in newborn boys
In vitro fertilization (IVF) in Sweden: risk for congenital malformations after different IVF methods
Are congenital anorectal malformations more frequent in newborns conceived with assisted reproductive techniques?
Periconceptional health and lifestyle factors of both parents affect the risk of live-born children with orofacial clefts
Non-VACTERL-type anomalies are frequent in patients with esophageal atresia/tracheo-esophageal fistula and full or partial VACTERL association
Maternal exposure to tobacco smoke, alcohol and caffeine, and risk of anorectal atresia: National Birth Defects Prevention Study 1997-2003
Research perspectives in the etiology of congenital anorectal malformations using data of the International Consortium on Anorectal Malformations: evidence for risk factors across different populations.
Parental risk factors of anorectal malformations: Analysis with a regional population-based control group
Birth outcomes of patients with isolated anorectal malformations - a population-based case-control study
Anorectal malformations and pregnancy-related disorders: a registry-based case-control study in 17 European regions
No major role for periconceptional folic acid use and its interaction with the MTHFR C677T polymorphism in the etiology of congenital anorectal malformations
Maternal and paternal environmental risk factors, metabolizing GSTM1 and GSTT1 polymorphisms, and congenital heart disease
Genome-wide mapping of copy number variations in patients with both anorectal malformations and central nervous system abnormalities
Investigating paternal preconception risk factors for adverse pregnancy outcomes in a population of internet users
Comparison in the incidence of anorectal malformations between a first- and third-world referral center
Comparison of environmental risk factors for esophageal atresia, anorectal malformations, and the combined phenotype in 263 German families
Effect of folic acid in a modified experimental model of anorectal malformations adriamycin-induced in rats
The effect of paternal factors on perinatal and paediatric outcomes: a systematic review and meta-analysis
Exome chip association study excluded the involvement of rare coding variants with large effect sizes in the etiology of anorectal malformations
Maternal intake of one-carbon metabolism-related B vitamins and anorectal malformations in the Japan Environment and Children's Study.
Comparison of Maternal Histories and Exposures in Children With Isolated Anorectal Malformation Versus Anorectal Malformation With Genitourinary Anomalies
Multicenter Study of 342 Anorectal Malformation Patients: Age, Gender, Krickenbeck Subtypes, and Associated Anomalies.
Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.