PMID: 7544450Sep 1, 1995Paper

Maternal and umbilical serum concentrations of granulocyte colony-stimulating factor and its messenger RNA during clinical chorioamnionitis

Obstetrics and Gynecology
Y LiR D Christensen

Abstract

To determine whether women with chorioamnionitis developed elevated serum granulocyte colony-stimulating factor (G-CSF) concentrations and, if so, whether the G-CSF crossed to the fetus. We quantified G-CSF before, during, and after delivery and in the cord blood of 12 women with clinical chorioamnionitis and 12 matched controls. We also measured G-CSF messenger RNA (mRNA) transcripts in mononuclear cells isolated from maternal and cord blood at delivery. At study entry, G-CSF concentrations were much higher in women with chorioamnionitis (1397 +/- 950 pg/mL, mean +/- standard error of mean) than in controls (17 +/- 5 pg/mL, P < .05). At delivery, concentrations had increased in both groups (2752 +/- 1100 pg/mL in the chorioamnionitis group, 165 +/- 61 pg/mL in controls; P < .05). After delivery, G-CSF concentrations had diminished to 839 +/- 594 pg/mL in women with chorioamnionitis and to 83 +/- 16 pg/mL in controls (P < .05). Concentrations in the cord blood were 2729 +/- 974 pg/mL for the chorioamnionitis group and 51 +/- 17 pg/mL for controls (P < .05). Granulocyte colony-stimulating factor mRNA transcripts were more abundant in women with chorioamnionitis than in controls but were scarce in all matched cord blood samples t...Continue Reading

Citations

Apr 1, 1997·Journal of Reproductive Immunology·K A BoggessW N Herbert
Apr 11, 1997·Schizophrenia Research·J H Gilmore, L F Jarskog
Apr 18, 2009·American Journal of Obstetrics and Gynecology·Masatoshi SaitoKunihiro Okamura
Aug 16, 2016·Mediators of Inflammation·Stefano MariniMassimo Di Giannantonio
Apr 16, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John H GilmoreJean M Lauder
Apr 29, 2015·The Journal of Nervous and Mental Disease·David CoxSabine Bahn
Aug 28, 1999·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·K MatsubaraM Ito
Feb 19, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yi XuNardhy Gomez-Lopez
Sep 15, 2000·Clinics in Perinatology·R D ChristensenL M Rimsza

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