Maternal androgen excess induces cardiac hypertrophy and left ventricular dysfunction in female mice offspring

Cardiovascular Research
Maria MantiElisabet Stener-Victorin

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrinopathy that is suggested to increase the risk for cardiovascular disease. How PCOS may lead to adverse cardiac outcomes is unclear and here we hypothesized that prenatal exposure to dihydrotestosterone (DHT) and/or maternal obesity in mice induce adverse metabolic and cardiac programming in female offspring that resemble the reproductive features of the syndrome. The maternal obese PCOS phenotype was induced in mice by chronic high-fat-high-sucrose consumption together with prenatal DHT exposure. The prenatally androgenized (PNA) female offspring displayed cardiac hypertrophy during adulthood, an outcome that was not accompanied by aberrant metabolic profile. The expression of key genes involved in cardiac hypertrophy was up-regulated in the PNA offspring, with limited or no impact of maternal obesity. Furthermore, the activity of NADPH oxidase, a major source of reactive oxygen species in the cardiovascular system, was down-regulated in the PNA offspring heart. We next explored for early transcriptional changes in the heart of newly born PNA offspring, which could account for the long-lasting changes observed in adulthood. Neonatal PNA hearts displayed an up-regulation of tr...Continue Reading

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Citations

Apr 21, 2020·Endocrine Reviews·Elisabet Stener-VictorinDavid H Abbott
Dec 4, 2019·Nature Medicine·Sanjiv RisalElisabet Stener-Victorin
Dec 13, 2019·Scientific Reports·Sarah HollandRebecca E Campbell
Dec 29, 2020·Journal of Cellular and Molecular Medicine·Wenting YeLili Zhou
Mar 7, 2021·Free Radical Biology & Medicine·Chrishan J A RamachandraDerek J Hausenloy
Jul 9, 2021·Nature Reviews. Endocrinology·Elisabet Stener-Victorin, Qiaolin Deng

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