Maternal antibody interference contributes to reduced rotavirus vaccine efficacy in developing countries.

PLoS Pathogens
Claire E OteroSallie R Permar

Abstract

Rotavirus (RV) vaccine efficacy is significantly reduced in lower- and middle-income countries (LMICs) compared to high-income countries. This review summarizes current research into the mechanisms behind this phenomenon, with a particular focus on the evidence that maternal antibody (matAb) interference is a contributing factor to this disparity. All RV vaccines currently in use are orally administered, live-attenuated virus vaccines that replicate in the infant gut, which leaves their efficacy potentially impacted by both placentally transferred immunoglobulin G (IgG) and mucosal IgA Abs conferred via breast milk. Observational studies of cohorts in LMICs demonstrated an inverse correlation between matAb titers, both in serum and breast milk, and infant responses to RV vaccination. However, a causal link between maternal humoral immunity and reduced RV vaccine efficacy in infants has yet to be definitively established, partially due to limitations in current animal models of RV disease. The characteristics of Abs mediating interference and the mechanism(s) involved have yet to be determined, and these may differ from mechanisms of matAb interference for parenterally administered vaccines due to the contribution of mucosal imm...Continue Reading

References

Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·M C KarlssonB Heyman
Jan 6, 2006·The New England Journal of Medicine·Guillermo M Ruiz-PalaciosUNKNOWN Human Rotavirus Vaccine Study Group
May 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Edouard TuaillonJean-Pierre Vendrell
May 6, 2010·The Pediatric Infectious Disease Journal·Sung-Sil MoonBaoming Jiang
Oct 23, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J G Lisciandro, A H J van den Biggelaar
Nov 15, 2011·Epidemiology and Infection·E BorràsUNKNOWN Working Group for the Study of Measles Immunity in Children
Jan 12, 2012·Clinical & Developmental Immunology·Patricia PalmeiraMagda Carneiro-Sampaio
Jan 16, 2014·The New England Journal of Medicine·W Katherine YihMichael Nguyen
Mar 6, 2015·The Pediatric Infectious Disease Journal·Sylvia Becker-DrepsBaoming Jiang
May 3, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michal PyzikRichard S Blumberg
Apr 10, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jacqueline E TateUNKNOWN World Health Organization–Coordinated Global Rotavirus Surveillance Network
Apr 22, 2017·The Journal of Infectious Diseases·Eleanor BurnettUmesh D Parashar
Apr 25, 2017·Vaccine·Sameer P NaikRajeev M Dhere
Feb 20, 2018·ImmunoHorizons·Genevieve G FoudaSallie R Permar
Feb 22, 2018·The New England Journal of Medicine·Julie E BinesYati Soenarto
Jun 22, 2019·PLoS Pathogens·Roberto Gozalbo-RoviraJesús Rodríguez-Díaz
Apr 1, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alisha M Gruntman, Terence R Flotte

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.