Maternal antidepressant use during pregnancy and neonatal hypoglycemia: prospective cohort study.

Journal of Perinatology : Official Journal of the California Perinatal Association
Jyotsna ShahPrakesh S Shah

Abstract

To evaluate associations between maternal antidepressant use during pregnancy and hypoglycemia in term neonates. We conducted a prospective comparative cohort study of neonates of ≥37 weeks' gestation. Neonates whose mothers used antidepressants during pregnancy were compared with randomly selected cohort of neonates whose mothers did not use antidepressants. Blood glucose was measured at 24 ± 2 h after birth. Hypoglycemia was defined as blood glucose level <2.6 mmol/L. We needed 60 patients in each group to reject the null hypothesis. Mean gestational ages were 39 vs. 40 weeks (p < 0.01) and birthweights were 3250 vs. 3360 g (p = 0.08) for antidepressant-exposed vs. -unexposed neonates. There were no significant differences between groups in odds of hypoglycemia (4/59: exposed vs. 2/61: unexposed; adjusted relative risk 1.73; 95% confidence interval [CI] 0.37-8.92) or mean blood glucose levels. Maternal antidepressant use during pregnancy was not associated with neonatal hypoglycemia at 24 h of age.

References

Nov 7, 2002·Archives of Pediatrics & Adolescent Medicine·Adriana Moldovan CosteiGideon Koren
Apr 7, 2004·Archives of Pediatrics & Adolescent Medicine·Bengt Källén
May 19, 2005·JAMA : the Journal of the American Medical Association·Eydie L Moses-KolkoKatherine L Wisner
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Dec 13, 2016·Pediatrics·Ulrika NörbyKarin Källén

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Citations

Sep 7, 2021·Acta Psychiatrica Scandinavica·Alexander KautzkyAnna Höflich

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Methods Mentioned

BETA
cesarean section

Software Mentioned

SAS

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