Maternal asthma is associated with increased risk of perinatal mortality

PloS One
Mari KemppainenTurkka Kirjavainen

Abstract

Asthma is the most common chronic disease during pregnancy and it may have influence on pregnancy outcome. Our goal was to assess the association between maternal asthma and the perinatal risks as well as possible effects of asthma medication. The study was based on a nationwide Finnish register-based cohort between the years 1996 and 2012 in the Drug and Pregnancy Database. The register data comprised 962 405 singleton live and stillbirths, 898 333 (93.3%) pregnancies in mothers with neither confirmed asthma nor use of asthma medication (controls), and 26 674 (2.8%) pregnancies with confirmed maternal asthma. 71% of mothers with asthma used asthma medication. The diagnosis of asthma was based on the mothers' right for subsidised medication which is carefully evaluated by strict criteria including pulmonary function testing. Odds ratio was used in comparison. Premature birth (PB), low birth weight, small for gestational age (SGA), neonatal death were the main outcome measures. Maternal asthma was associated with adjusted odds ratios (aORs) for perinatal mortality 1.24 (95% CI 1.05 to 1.46), preterm birth 1.18 (1.11 to 1.25), low birth weight 1.29 (1.21 to 1.37), fetal growth restriction (SGA) 1.32, (1.24 to 1.40), and asphyxia ...Continue Reading

References

Oct 1, 1992·American Journal of Obstetrics and Gynecology·J H PerlowM Porto
Jan 1, 1988·Thorax·B Stenius-AarnialaK Teramo
Mar 1, 1995·Scandinavian Journal of Social Medicine·M GisslerJ Meriläinen
Apr 1, 1996·Thorax·B S Stenius-AarnialaK A Teramo
Jul 4, 1998·Pediatrics·K DemissieG G Rhoads
Jun 21, 2001·Respiration; International Review of Thoracic Diseases·C OlesenUNKNOWN EuroMAP Group
Jan 4, 2006·American Journal of Obstetrics and Gynecology·Michael SchatzUNKNOWN National Heart, Lung, and Blood Institute
Jan 31, 2006·Immunology and Allergy Clinics of North America·Helen L KwonMichael B Bracken
Feb 1, 2007·European Journal of Clinical Pharmacology·Bengt Källén, Petra Otterblad Olausson
Feb 1, 2007·European Journal of Clinical Pharmacology·Bengt Källén, Petra Otterblad Olausson
Feb 7, 2007·European Journal of Clinical Pharmacology·Bengt Källén, Petra Otterblad Olausson
Aug 17, 2010·American Journal of Obstetrics and Gynecology·Jun ZhangUNKNOWN Consortium on Safe Labor
Jun 1, 2011·Pharmacoepidemiology and Drug Safety·Miia ArtamaUNKNOWN Drugs and Pregnancy Study Group
Jul 14, 2011·BJOG : an International Journal of Obstetrics and Gynaecology·V E MurphyP G Gibson
Jan 1, 2010·Multidisciplinary Respiratory Medicine·Lilla TamásiGyörgy Losonczy
Nov 20, 2012·American Journal of Obstetrics and Gynecology·Pauline MendolaJun Zhang
Jan 10, 2013·Primary Care Respiratory Journal : Journal of the General Practice Airways Group·Annette KainuAnne Pietinalho
Aug 7, 2013·The Journal of Allergy and Clinical Immunology·Pauline MendolaS Katherine Laughon
Dec 18, 2013·The European Respiratory Journal·Kian Fan ChungW Gerald Teague
Feb 28, 2014·BJOG : an International Journal of Obstetrics and Gynaecology·S Meher, Z Alfirevic
Jan 19, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Kristin PalmstenChristina D Chambers

❮ Previous
Next ❯

Citations

Nov 9, 2018·Current Opinion in Pulmonary Medicine·Annelies L RobijnPeter G Gibson
Jul 30, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Annelies L RobijnVanessa E Murphy
Sep 30, 2020·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Alia YousifUNKNOWN TORSADE Cohort Working Group
Sep 30, 2020·Expert Opinion on Pharmacotherapy·Ruth P Cusack, Gail M Gauvreau
Mar 20, 2020·Allergy·Birgit PfallerThomas Eiwegger
Feb 6, 2020·The Journal of Allergy and Clinical Immunology. in Practice·Cristina LongoLucie Blais
Sep 28, 2020·The Journal of Pediatrics·Niels B MatthiesenTine B Henriksen
Nov 11, 2020·American Journal of Epidemiology·Danielle R StevensPauline Mendola
Mar 12, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Gustaf RejnöCatarina Almqvist
Jun 2, 2021·Expert Review of Respiratory Medicine·Jennifer A Namazy, Michael Schatz
Jul 27, 2021·Case Reports in Obstetrics and Gynecology·Takeshi MurakamiTomihiro Shimamoto
Aug 18, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Marleen P BokernVanessa E Murphy
Oct 14, 2021·Human Reproduction Update·Laura A WijsRoger J Hart
Oct 18, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Danielle R StevensPauline Mendola

❮ Previous
Next ❯

Methods Mentioned

BETA
SGA

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.