Maternal betaine supplementation affects fetal growth and lipid metabolism of high-fat fed mice in a temporal-specific manner

Nutrition & Diabetes
Yaelle JoselitXinyin Jiang

Abstract

Maternal obesity increases the risk of gestational diabetes mellitus (GDM), which results in fetal overgrowth and long-lasting metabolic dysfunctioning in the offspring. Previous studies show that maternal choline supplementation normalizes fetal growth and adiposity of progeny from obese mice. This study examines whether supplementation of betaine, a choline derivative, has positive effects on fetal metabolic outcomes in mouse progeny exposed to maternal obesity and GDM. C57BL/6J mice were fed either a high-fat (HF) diet or a control (normal-fat, NF) diet and received either 1% betaine (BS) or control untreated (BC) drinking water 4-6 weeks before timed-mating and throughout gestation. Maternal, placental, and fetal samples were collected for metabolite and gene-expression assays. At E12.5, BS prevented fetal and placental overgrowth and downregulated glucose and fatty acid transporters (Glut1 and Fatp1) and the growth-promoting insulin-like growth factor 2 (Igf2) and its receptor Igf1r in the placenta of HF, glucose-intolerant dams (P < 0.05). However, these effects disappeared at E17.5. At E17.5, BS reduced fetal adiposity and prevented liver triglyceride overaccumulation in HF versus NF fetuses (P < 0.05). BS fetal livers h...Continue Reading

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Citations

Feb 20, 2019·Experimental Biology and Medicine·Vera Hedtke, Marica Bakovic
Aug 10, 2019·Nutrients·Hunter W KorsmoMarie A Caudill
Jun 26, 2020·Archives of Gynecology and Obstetrics·Pouya SalahiMasoud Alirezaei
Jun 3, 2021·Biology·Madan Kumar ArumugamKusum K Kharbanda
Jun 12, 2021·The American Journal of Clinical Nutrition·Carolina Moltó-PuigmartíCarel Thijs
Jul 3, 2021·Trends in Endocrinology and Metabolism : TEM·Hunter W Korsmo, Xinyin Jiang
Apr 6, 2021·Nutrition Research Reviews·Weiqiang ChenLiefeng Wang

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Methods Mentioned

BETA
dissection
PCR
enzyme-linked immunosorbent assay
Assay

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