Maternal blood folate status during early pregnancy and occurrence of autism spectrum disorder in offspring: a study of 62 serum biomarkers

Molecular Autism
Olga EgorovaSven-Arne Silfverdal

Abstract

Autism spectrum disorder (ASD) evolves from an interplay between genetic and environmental factors during prenatal development. Since identifying maternal biomarkers associated with ASD risk in offspring during early pregnancy might result in new strategies for intervention, we investigated maternal metabolic biomarkers in relation to occurrence of ASD in offspring using both univariate logistic regression and multivariate network analysis. Serum samples from 100 women with an offspring diagnosed with ASD and 100 matched control women with typically developing offspring were collected at week 14 of pregnancy. Concentrations of 62 metabolic biomarkers were determined, including amino acids, vitamins (A, B, D, E, and K), and biomarkers related to folate (vitamin B9) metabolism, lifestyle factors, as well as C-reactive protein (CRP), the kynurenine-tryptophan ratio (KTR), and neopterin as markers of inflammation and immune activation. We found weak evidence for a positive association between higher maternal serum concentrations of folate and increased occurrence of ASD (OR per 1 SD increase: 1.70, 95% CI 1.22-2.37, FDR adjusted P = 0.07). Multivariate network analysis confirmed expected internal biochemical relations between the b...Continue Reading

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Citations

Aug 28, 2020·The American Journal of Clinical Nutrition·Ramkripa RaghavanXiaobin Wang
Oct 6, 2020·Autism Research : Official Journal of the International Society for Autism Research·Caichen ZhongKristen Lyall
Nov 20, 2020·Clinical & Translational Immunology·Stefano SotgiuAlessandra Carta
Jan 23, 2021·International Journal of Molecular Sciences·Hendrik NieraadGerd Geisslinger
Mar 21, 2021·Journal of Autism and Developmental Disorders·Xian LiuWen-Xiong Chen
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yulia ShulpekovaVladimir Ivashkin
Aug 30, 2021·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Rui ZhaoLihong Liu

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