Maternal Blood Manganese and Early Neurodevelopment: The Mothers and Children's Environmental Health (MOCEH) Study

Environmental Health Perspectives
Soo Eun ChungSe-young Oh

Abstract

Manganese is an essential trace element and common component of water, soil, and air. Prenatal manganese exposure may affect fetal and infantile neurodevelopment, but reports on in utero manganese exposure and infant neurodevelopment are rare. This study was conducted to investigate a relationship between maternal blood manganese level and neurodevelopment of infants at 6 months of age. Data were obtained from the Mothers and Children's Environmental Health (MOCEH) birth cohort study. The study population included 232 pairs of pregnant women and their infants at 6 months of age. Maternal blood manganese was measured at term, just before delivery. Mental and psychomotor development in infancy was assessed at 6 months of age using the Bayley Scales of Infant Development. The relationship between maternal blood manganese level and the mental and psychomotor development indexes (MDI and PDI) was estimated for manganese modeled as a linear and as a categorical variable and using penalized splines for nonlinear modeling. Mean ± SD maternal blood manganese concentration was 22.5 ± 6.5 μg/L. After adjustment for potential confounders, blood manganese was used as a continuous variable in a linear and nonlinear model. Associations betwee...Continue Reading

References

Dec 1, 1994·The American Journal of Clinical Nutrition·J W FinleyL K Johnson
Mar 1, 1995·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·K TholinG Hallmans
Sep 19, 1998·Journal of Korean Medical Science·J W KimK Ito
Jun 11, 2002·Environmental Health Perspectives·Alan WoolfDavid Bellinger
Sep 29, 2004·Neurotoxicology and Teratology·L TakserJ Lafond
Aug 16, 2005·Molecular Aspects of Medicine·Judy L Aschner, Michael Aschner
Jan 6, 2006·Environmental Health Perspectives·Gail A WassermanJoseph H Graziano
Nov 7, 2006·Pharmacology & Therapeutics·Keith M EriksonMichael Aschner
Mar 21, 2007·Environmental Health Perspectives·Maryse BouchardDonna Mergler
Apr 24, 2007·Environmental Health Perspectives·Daniel A AxelradTracey J Woodruff
Feb 5, 2008·Reproductive Toxicology·Mohsen VigehShunichi Araki
Mar 18, 2009·Epidemiology·Ami R ZotaRobert O Wright
Jul 25, 2009·European Journal of Epidemiology·Byung-Mi KimUNKNOWN MOCEH Study Group
Jan 16, 2010·Journal of Toxicology and Environmental Health. Part a·William K Boyes
Jun 16, 2010·Epidemiology·Birgit Claus HennRobert O Wright
Sep 22, 2010·Environmental Health Perspectives·Maryse F BouchardDonna Mergler
Oct 15, 2010·Environmental Research·José A Menezes-FilhoDonna Mergler
May 31, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Miyoung YoonHarvey J Clewell
Sep 3, 2011·Environmental Health Perspectives·Birgit Claus HennMartha María Téllez-Rojo
Dec 21, 2011·Neurotoxicology·Khalid KhanPam Factor-Litvak
Mar 15, 2013·Current Opinion in Pediatrics·Silvia Zoni, Roberto G Lucchini
Apr 13, 2013·Environmental Research·Ching-Chun LinPau-Chung Chen
Apr 30, 2013·Neurotoxicology and Teratology·Stephane A BeaudinDonald R Smith

❮ Previous
Next ❯

Citations

Aug 2, 2015·Current Environmental Health Reports·Stefanie L O'Neal, Wei Zheng
Jul 22, 2017·Neurotoxicology·Teresa Verenice Muñoz-RochaMartha María Téllez-Rojo
May 31, 2018·Environmental Health Perspectives·Ana María MoraBerna van Wendel de Joode
Feb 23, 2019·Nihon eiseigaku zasshi. Japanese journal of hygiene·Miyuki Iwai-ShimadaKyoko Nomura
Jan 7, 2016·Journal of Exposure Science & Environmental Epidemiology·Cynthia K ColapintoWilliam Fraser
Jun 20, 2019·Molecular Nutrition & Food Research·Benjamin SachseBernd Schäfer
Mar 8, 2020·International Journal of Environmental Research and Public Health·Ainara AndiarenaAitana Lertxundi
Apr 23, 2016·Environmental Science and Pollution Research International·Pan ChenMichael Aschner
Mar 20, 2020·The Journal of Biological Chemistry·Rekha C BalachandranAaron B Bowman
Dec 20, 2018·Journal of Exposure Science & Environmental Epidemiology·Antonio J Signes-PastorMargaret R Karagas
Apr 20, 2019·Journal of Exposure Science & Environmental Epidemiology·Shoji F NakayamaUNKNOWN Japan Environment and Children’s Study Group
Sep 7, 2020·Journal of Autism and Developmental Disorders·Mohammad H RahbarKatherine A Loveland
Jan 26, 2017·Environmental Toxicology and Chemistry·Hongwei TuFei Zou
Dec 21, 2017·Reproductive Medicine and Biology·Ryo MaekawaNorihiro Sugino
Oct 17, 2019·World Journal of Pediatrics : WJP·Joyce TienJianghong Liu
Sep 1, 2016·Environmental Health : a Global Access Science Source·Donna J CoetzeeIrina Stepanov
Oct 6, 2020·Journal of Exposure Science & Environmental Epidemiology·Mona DaiGlenn E Rice
Jan 17, 2020·The Science of the Total Environment·Shengju YinAiguo Ren
Feb 21, 2019·Environmental Research·Midori YamamotoUNKNOWN Japan Environment and Children's Study Group:
Apr 16, 2021·Environmental Research·Amaia IrizarAitana Lertxundi
May 1, 2021·International Journal of Molecular Sciences·Alexey A TinkovMichael Aschner
Jun 22, 2021·Exposure & Health·Antonio J Signes-PastorKatarzyna Kordas
Sep 9, 2017·Environment International·Andrea E Cassidy-BushrowManish Arora

❮ Previous
Next ❯

Methods Mentioned

BETA
GAM

Software Mentioned

Pro
CAN
R
HEAT
SAS

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.