Maternal BMI, Mid-pregnancy Fatty Acid Concentrations,and Perinatal Outcomes

Clinical Therapeutics
Annie Penfield-CyrSarbattama Sen

Abstract

Maternal body mass index (BMI) and systemic fatty acid (FA) concentrations affect inflammatory balance in pregnancy and play a key role in fetal growth and well-being. Little is known about how maternal BMI may affect the association between key FA concentrations and neonatal outcomes. The objective of this study was to examine the associations between the maternal omega (n)6:n3 FA ratio and neonatal outcomes according to maternal pre-pregnancy BMI category. This study is a secondary analysis of the Maternal-Fetal Medicine Units Network randomized controlled trial of omega-3 FA supplementation to prevent recurrent preterm birth. At consent (16-22 weeks of pregnancy), women were randomized to either the intervention arm (2g of n3 FAs) or the control arm (placebo). For the present analysis, the primary exposure was the ratio of proinflammatory to anti-inflammatory (n6:n3) FAs at 25 to 28 weeks of pregnancy. The primary outcome was fetal growth as measured by using birth-weight-for-gestational-age z score, birth-length-for-gestational-age z score, and head-circumference-for-gestational-age z score. BMI categories were defined as lean (18.5-24.9 kg/m²) and overweight/obese (OWOB) (≥25.0 kg/m²). Final analysis was stratified accordi...Continue Reading

Citations

Nov 28, 2018·The Cochrane Database of Systematic Reviews·Philippa MiddletonMaria Makrides
Nov 30, 2020·Journal of Perinatology : Official Journal of the California Perinatal Association·Lilin Tong, Brian T Kalish
Mar 21, 2021·The American Journal of Clinical Nutrition·Runyu ZouHenning Tiemeier

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