Maternal caffeine intake during pregnancy and risk of pregnancy loss: a categorical and dose-response meta-analysis of prospective studies

Public Health Nutrition
Ling-Wei ChenRob M Van Dam

Abstract

To assess the association between maternal caffeine intake and risk of pregnancy loss using a systematic review and meta-analysis. Categorical and dose-response meta-analysis of prospective studies. Relevant articles were identified by searching MEDLINE and SCOPUS databases through 30 January 2015. Two authors independently extracted information from eligible studies. Random-effects models were used to derive the summary relative risks (RR) and corresponding 95% CI for specific categories of caffeine consumption and for a continuous association using generalized least-squares trend estimation. A total of 130 456 participants and 3429 cases in fourteen included studies. Compared with the reference category with no or very low caffeine intake, the RR (95% CI) of pregnancy loss was 1·02 (0·85, 1·24; I(2)=28·3%) for low intake (50-149 mg/d), 1·16 (0·94, 1·41; I 2=49·6%) for moderate intake (150-349 mg/d), 1·40 (1·16, 1·68; I(2)=18·6%) for high intake (350-699 mg/d) and 1·72 (1·40, 2·13; I(2)=0·0%) for very high intake (≥ 700 mg/d). In the dose-response analysis, each 100 mg/d increment in maternal caffeine intake (~1 cup of coffee) was associated with 7% (95% CI 3%, 12%) higher risk of pregnancy loss. Our results may have been affe...Continue Reading

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Citations

Apr 26, 2017·Current Opinion in Psychiatry·Amy PeacockRaimondo Bruno
Jan 3, 2018·European Journal of Public Health·Maria Morales-Suárez-VarelaBodil H Bech
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Feb 23, 2020·Purinergic Signalling·D Pereira-FigueiredoK C Calaza
Dec 1, 2020·Obstetrical & Gynecological Survey·Ioannis TsakiridisMichail Chourdakis

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