Maternal cardiac function during pregnancy at high altitude

BJOG : an International Journal of Obstetrics and Gynaecology
N A KametasKypros Nicolaides

Abstract

To investigate the maternal cardiovascular adaptation in pregnancy at high altitude, compared with that at sea level. Cross sectional study. Two maternity units providing routine antenatal care: one at 4370 m above sea level (Cerro de Pasco, Peru) and one at sea level (Lima, Peru). We examined 175 pregnant women at 5-41 weeks of gestation and 16 non-pregnant controls resident at high altitude and 132 pregnant women and 18 non-pregnant controls at sea level. Two-dimensional and M-mode echocardiography of the left ventricle. Maternal cardiac output and left ventricular longitudinal and transverse systolic function indices. Pregnancy at high altitude, compared with sea level, is associated with 11% lower birthweight and 31% lower maternal cardiac output, due to 15% lower stroke volume and 11% lower heart rate. The lower stroke volume was due to a lower preload and impaired longitudinal and transverse left ventricular systolic function. Mean arterial pressure was about 8% lower during pregnancy at high altitude versus sea level. Pregnant women at high altitude failed to expand their intravascular space to the same extent as the sea level group: cardiac output increased by 17%, left atrial diameter by 12% and end-diastolic diameter ...Continue Reading

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Citations

Feb 18, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Vaughn A BrowneLorna G Moore
Jun 26, 2012·High Altitude Medicine & Biology·Dominique Jean, Lorna G Moore
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May 24, 2021·American Journal of Obstetrics & Gynecology MFM·Imogen D GrantCatherine E Aiken

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