Maternal cardiac function in women at high-risk for preeclampsia treated with 150mg Aspirin or placebo: an observational study

BJOG : an International Journal of Obstetrics and Gynaecology
Hua Zen LingN A Kametas

Abstract

To compare maternal haemodynamics in women low and high-risk for preterm pre-eclampsia (PE) and between those high-risk randomised to aspirin or placebo. Prospective, longitudinal observational study. Maternity units in six UK hospitals. Women participating in the Aspirin for Prevention of Preterm Pre-eclampsia (ASPRE) trial. The population comprised of three groups of women: low-risk for preterm PE (N=1362), high-risk for preterm PE treated with aspirin (N=208), and high-risk for preterm PE on placebo (N=220). Women had four visits during pregnancy: 11-14, 19-24, 30-34- and 35-37 weeks' gestation. Blood pressure was measured with a device validated for pregnancy and PE and maternal haemodynamics were assessed with a bioreactance monitor at each visit. A multilevel linear mixed-effects analysis was performed to examine longitudinal changes of maternal haemodynamic variables, controlling for demographic characteristics, past medical history and medication use. Longitudinal changes of cardiac output (CO), mean arterial pressure (MAP) and peripheral vascular resistance (PVR). The low-risk group demonstrated the expected changes with an increase in CO and reduction in MAP and PVR, with a quadratic change across gestation. On the co...Continue Reading

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Citations

Oct 17, 2020·Pregnancy Hypertension·Laura SarnoMaurizio Guida
Aug 10, 2020·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·R J Martinez-PortillaF Figueras

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