Maternal cardiovascular and endothelial function from first trimester to postpartum

PloS One
Vassiliki Kolovetsiou-KreinerHelmut Karl Lackner

Abstract

To explore noninvasively the complex interactions of the maternal hemodynamic system throughout pregnancy and the resulting after-effect six weeks postpartum. Eighteen women were tested beginning at the 12th week of gestation at six time-points throughout pregnancy and six weeks postpartum. Heart rate, heart rate variability, blood pressure, pulse transit time (PTT), respiration, and baroreceptor sensitivity were analyzed in resting conditions. Additionally, hemoglobin, asymmetric and symmetric dimethylarginine and Endothelin (ET-1) were obtained. Heart rate and sympathovagal balance favoring sympathetic drive increased, the vagal tone and the baroreflex sensitivity decreased during pregnancy. Relative sympathetic drive (sympathovagal balance) reached a maximum at 6 weeks postpartum whereas the other variables did not differ compared to first trimester levels. Postpartum diastolic blood pressure was higher compared to first and second trimester. Pulse transit time and endothelial markers showed no difference throughout gestation. However, opposing variables PTT and asymmetric dimethylarginine (ADMA) were both higher six weeks postpartum. The sympathetic up regulation throughout pregnancy goes hand in hand with a decreased baror...Continue Reading

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Citations

Mar 31, 2019·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Onur TasarCevat Kirma
Jun 30, 2019·International Journal of Molecular Sciences·Helmut K LacknerManfred G Moertl
Jan 26, 2020·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Priyanka GargKishore Kumar Deepak
Dec 29, 2020·Journal of Applied Physiology·Victoria L MeahMargie H Davenport
Jul 15, 2021·Journal of the American Heart Association·Rachel A BrightKathleen Stergiopoulos

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