Maternal carriers of the ANXA5 M2 haplotype are exposed to a greater risk for placenta-mediated pregnancy complications

Journal of Assisted Reproduction and Genetics
Federico ArandaGabriela de Larrañaga

Abstract

Annexin A5 (ANXA5) is a protein abundantly expressed in normal placenta where it contributes to the healthy outcome of a pregnancy. Lower ANXA5 levels have been observed in M2/ANXA5 haplotype carrying chorion. Consequently, this study aimed to assess the potential association of M2 maternal carrier status with the risk of recurrent pregnancy loss (RPL), the timing of miscarriages, and other obstetric complications, for the first time in a population from Latin America. This study was designed as a prospective recruitment of RPL patients with post hoc analysis. The distribution of the M2/ANXA5 haplotype was compared between a group of 229 Argentine women with RPL and 100 parous controls, and was further analyzed in subgroups of patients stratified according to the timing of miscarriages and in relation to other obstetric complications. No significant differences were found in the distribution of M2 haplotype among either RPL patients or the subgroups with embryonic, early fetal, or late fetal losses compared to parous controls. Notwithstanding, maternal M2/ANXA5 was found to be independently associated with a higher risk of suffering intrauterine growth restriction (IUGR) and/or preeclampsia (PE). Simultaneously, the presence of...Continue Reading

References

Oct 1, 1996·American Journal of Obstetrics and Gynecology·D S Dizon-TownsonK Ward
Jan 8, 1999·The New England Journal of Medicine·M J KupfermincJ B Lessing
Apr 17, 2001·American Journal of Obstetrics and Gynecology·D W BranchUNKNOWN National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network
Oct 10, 2001·Fertility and Sterility·H MatsubayashiT Makino
Mar 22, 2003·Lancet·Evelyne ReyIan Shrier
May 24, 2003·Best Practice & Research. Clinical Haematology·Elvira Grandone, Maurizio Margaglione
Jan 9, 2004·Fertility and Sterility·UNKNOWN Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group
Apr 3, 2004·Seminars in Perinatology·Susan E OzanneC Nicholas Hales
Oct 28, 2004·Thrombosis Research·Jacob H Rand, Xiao-Xuan Wu
Mar 7, 2007·Human Molecular Genetics·Nadia BogdanovaArseni Markoff
Apr 17, 2007·Seminars in Hematology·Saskia Middeldorp
Jul 22, 2008·Journal of Clinical Pathology·D J Roberts, M D Post
Mar 21, 2009·Obstetrics and Gynecology
Aug 5, 2009·Thrombosis and Haemostasis·Giovanni TisciaElvira Grandone
Dec 26, 2009·Thrombosis Research·Stavros SifakisDemetrios A Spandidos
Jan 12, 2010·Annals of Human Genetics·Daniel CorachManfred Kayser
Feb 23, 2010·Thrombosis and Haemostasis·Pal B SzecsiSteen Stender
Jun 29, 2010·American Journal of Obstetrics and Gynecology·Cara HeuserRobert M Silver
Jan 19, 2011·Acta Obstetricia Et Gynecologica Scandinavica·Minna Tikkanen
Jan 26, 2011·Thrombosis Research·Berthold Huppertz
Feb 4, 2011·Molecular Human Reproduction·Hironori MiyamuraHiroki Kurahashi
Jul 27, 2011·Thyroid : Official Journal of the American Thyroid Association·Alex Stagnaro-GreenUNKNOWN American Thyroid Association Taskforce on Thyroid Disease During Pregnancy and Postpartum
Jan 13, 2012·The Journal of Clinical Endocrinology and Metabolism·Steven D Chernausek
Apr 17, 2012·PloS One·Sergio AvenaLaura Fejerman
Oct 26, 2012·Fertility and Sterility·UNKNOWN Practice Committee of American Society for Reproductive Medicine
Dec 12, 2012·Nature Medicine·Jeeyeon ChaSudhansu K Dey
Mar 15, 2013·Thrombosis Research·Michal KovoJacob Bar
Mar 28, 2013·American Journal of Obstetrics and Gynecology·Julia UnterscheiderFergal Desmond Malone
Jun 28, 2013·BMC Medicine·Elisabeth Clare LarsenNick Macklon
Jan 8, 2014·Thrombosis Research·Victor GourvasStavros Sifakis
Nov 8, 2014·Human Reproduction·A M KolteUNKNOWN ESHRE Special Interest Group, Early Pregnancy
Feb 24, 2015·Placenta·A BouterA R Brisson
Dec 5, 2015·PLoS Genetics·Julian R HomburgerCarlos D Bustamante

❮ Previous
Next ❯

Citations

Nov 25, 2020·Journal of Assisted Reproduction and Genetics·Nina RogenhoferChristian Thaler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.