PMID: 9637577Jun 24, 1998Paper

Maternal cell-free viremia in the natural history of perinatal HIV-1 transmission: a meta-analysis

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association
D G Contopoulos-Ioannidis, John P A Ioannidis

Abstract

We performed a meta-analysis of the predictive value of maternal cell-free viral load in vertical HIV-1 transmission, including 9 cohorts with 1115 mother-infant pairs (696 untreated and 419 treated women). The pooled rate of transmission in untreated women was 21.3% (95% confidence interval [CI], 18.3%-24.5%). The rates of transmission for untreated women in the <1000 copies/ml, 1000 to 9999 copies/ml, and > or = 10,000 copies/ml categories were 5% (95% CI, 2%-11%), 15% (95% CI, 11%-20%) and 37% (95% CI, 29%-46% by random effects), respectively. The area under the receiver operating characteristic (ROC) curve in individual studies ranged from 0.67 to 1.00. The predictive performance of RNA differed between cohorts in which different percentages of transmitters had RNA values >10,000 copies/ml. When 95% of transmitters have RNA values >1000 copies/ml, 77% of nontransmitters would also have values above this cutoff. Transmission rates for treated women in the 1000 to 9999 copies/ml category (7%; 95% CI, 4%-11%,) and > or = 10,000 copies/ml category (18%; 95% CI, 12%-27%) were probably lower than those for untreated women, whereas the transmission rate for treated women with <1000 copies/ml was 5% (95% CI, 2%-11 %). Thus, the ris...Continue Reading

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Citations

Jul 27, 2001·Current Infectious Disease Reports·Jaime Deville, Yvonne Bryson
Nov 30, 2000·Current Infectious Disease Reports·M Holodniy
Sep 21, 2001·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·W Holmes, T Kwarteng
Apr 1, 1999·The New England Journal of Medicine·UNKNOWN International Perinatal HIV GroupR Tuomala
Apr 1, 1999·The New England Journal of Medicine·L E Riley, M F Greene
Dec 28, 1999·The New England Journal of Medicine·J P Ioannidis, D G Contopoulos-Ioannidis
May 10, 2001·Clinical Obstetrics and Gynecology·M Khoury, A Kovacs
Jan 7, 2003·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Despina G Contopoulos-IoannidisJohn P A Ioannidis
Feb 19, 2008·The Pediatric Infectious Disease Journal·Charles ChaselaJennifer S Read
Mar 24, 2012·AIDS·Phillip J ReadUNKNOWN London HIV Perinatal Research Group
Mar 13, 2010·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Ying Q ChenJennifer S Read
Aug 17, 1999·Sexually Transmitted Infections·G P TaylorG Tudor-Williams
Jul 19, 2001·AIDS Education and Prevention : Official Publication of the International Society for AIDS Education·K SiegelJ K Johnson
Oct 17, 2008·Current Problems in Pediatric and Adolescent Health Care·Jennifer S ReadSusan Schuval
Dec 22, 1999·AIDS Research and Human Retroviruses·V ZacharA S Goustin
Oct 16, 2004·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Isis S MikhailPauline E Jolly
Apr 18, 2003·AIDS·Karolynn Siegel, Helen-Maria Lekas
Oct 13, 2006·Current Opinion in Infectious Diseases·G Tudor-Williams, E G Lyall
May 30, 2020·PloS One·Matthew SandbulteSarah Finocchario-Kessler

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