Maternal cigarette smoking during pregnancy is associated with downregulation of miR-16, miR-21, and miR-146a in the placenta.

Epigenetics : Official Journal of the DNA Methylation Society
Matthew A MaccaniCarmen J Marsit

Abstract

Maternal cigarette smoking during pregnancy is associated with poor fetal outcome and aberrant miRNA expression is associated with adverse pregnancy outcomes. In 25 human placentas, we analyzed the expression of four candidate miRNA previously implicated in growth and developmental processes: miR-16, miR-21, miR-146a, and miR-182, and used three immortalized placental cell lines to identify if specific components of cigarette smoke were responsible for alterations to miRNA expression. miR-16, miR-21, and miR-146a were significantly downregulated in cigarette smoke-exposed placentas compared to controls. TCL-1 cells exposed to both nicotine and benzo(a)pyrene exhibited significant, dose-dependent downregulation of miR-146a. These results suggest that miR-146a is particularly responsive to exposures, and that smoking may elicit some of its downstream effects through alteration of miRNA expression.

References

Apr 5, 1980·British Medical Journal·M A RussellC Feyerabend
Apr 1, 1996·Seminars in Perinatology·D S Lambers, K E Clark
Apr 13, 1999·American Journal of Preventive Medicine·A CastlesM L Boulton
Feb 24, 2001·American Journal of Public Health·N JaakkolaJ J Jaakkola
Aug 3, 2002·Science·György Hutvágner, Phillip D Zamore
Jun 19, 2004·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Sven Cnattingius
Jun 21, 2005·Nature Genetics·Isaac BentwichZvi Bentwich
Aug 16, 2005·Current Opinion in Genetics & Development·Eric A Miska
Feb 7, 2006·Current Biology : CB·Sabbi LallNikolaus Rajewsky
Jul 18, 2006·Nucleic Acids Research·Jan Krüger, Marc Rehmsmeier
Aug 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Konstantin D TaganovDavid Baltimore
Nov 17, 2006·Cancer Research·Carmen J MarsitKarl T Kelsey
Mar 10, 2007·American Journal of Obstetrics and Gynecology·Beth L PinelesChong Jai Kim
Apr 3, 2007·Obstetrics and Gynecology·Renee D GoodwinNicole Simuro
May 4, 2007·Biochemical and Biophysical Research Communications·Nham TranBarbara Rose
Aug 19, 2007·Cell Research·Tingting Du, Phillip D Zamore
Apr 18, 2008·Molecular Biology and Evolution·Rui ZhangBing Su
May 20, 2008·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Anja ThielenLutz Müller
Jan 27, 2009·European Journal of Clinical Pharmacology·Adrienne Einarson, Sara Riordan
Feb 12, 2009·PloS One·Stefan LehnertFrans C Schuit
Mar 3, 2009·Biology of the Cell·Tagrid KaddarJean-Pierre Magaud
Jun 19, 2009·The EMBO Journal·Joris PothofStephan P Persengiev
Jul 15, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jin HouXuetao Cao
Jul 16, 2009·The Journal of Reproduction and Development·Dusan FabianJuraj Koppel
Aug 6, 2009·Biochemical and Biophysical Research Communications·Melissa CrawfordSerge P Nana-Sinkam
Sep 8, 2009·BMC Genomics·Hai Yang HuPhilipp Khaitovich
Nov 20, 2009·Epigenetics : Official Journal of the DNA Methylation Society·Kuo-Wang TsaiWen-chang Lin
Dec 10, 2009·Molecular Human Reproduction·Liping LiWeihua Lei
Feb 16, 2010·Biochemical and Biophysical Research Communications·Martina WeberCharles D Searles
Feb 26, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Slava RomFrancesca Peruzzi
Mar 2, 2010·Biochemical and Biophysical Research Communications·Jia-feng WangKe-ming Zhu
Apr 27, 2010·Reproductive Toxicology·Michele Avissar-WhitingCarmen J Marsit

❮ Previous
Next ❯

Citations

Oct 16, 2012·Development and Psychopathology·Valerie S KnopikJohn E McGeary
Jul 6, 2014·Journal of Developmental Origins of Health and Disease·A M Vaiserman
Jun 21, 2013·Pediatric Research·Matthew A MaccaniCarmen J Marsit
Oct 4, 2012·Stem Cells and Development·Tsz Kin NgHerman S Cheung
Sep 6, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Suena H Massey, Michael T Compton
May 24, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Wataru YoshiokaChiharu Tohyama
Jun 8, 2012·Environmental Health Perspectives·Kim BoekelheideJohn M Rogers
Jun 24, 2011·PloS One·Matthew A MaccaniCarmen J Marsit
Mar 8, 2012·Clinical Chemistry·Zhen ZhaoAnn M Gronowski
Nov 30, 2011·Epigenomics·Jorge Alejandro Alegría-TorresValentina Bollati
Mar 19, 2014·Current Opinion in Pediatrics·Maya Kappil, Jia Chen
Mar 28, 2012·Epigenomics·Ivana V Yang
Nov 8, 2012·Epigenomics·Sue-Ann Lee, Chunming Ding
Feb 25, 2014·International Journal of Hygiene and Environmental Health·A Izzotti, A Pulliero
May 3, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·H JiangG Xu
Aug 26, 2014·Paediatric Respiratory Reviews·Olena GruzievaErik Melén
Feb 5, 2015·International Journal of Environmental Research and Public Health·Francesca PiriniRafael Guerrero-Preston
Apr 9, 2014·Journal of Molecular Biology·Catherine J PeñaEric J Nestler
Sep 15, 2014·Molecular Genetics and Metabolism·S F DobrowolskiT Sultana
Jun 4, 2013·Toxicology and Applied Pharmacology·Kei TakahashiMiki Nakajima
Apr 7, 2015·European Psychiatry : the Journal of the Association of European Psychiatrists·M MelchiorUNKNOWN EDEN Mother-Child Cohort Study Group
Oct 16, 2012·Seminars in Cell & Developmental Biology·Chandan K Sen, Sashwati Roy
Jun 19, 2012·Clinical Epigenetics·Matthew A Maccani, Carmen J Marsit
Mar 1, 2011·Journal of Reproductive Immunology·Diana M Morales Prieto, Udo R Markert
Oct 26, 2010·Virus Research·Kavitha DhuruvasanPhilip E Pellett
Apr 2, 2016·Research in Veterinary Science·Wei NiRenzhe Quan
Sep 15, 2015·Frontiers in Neuroendocrinology·Bridget M Nugent, Tracy L Bale
Mar 23, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Jean-Francois MouilletYoel Sadovsky
Jan 29, 2013·Prenatal Diagnosis·Ai HigashijimaHideaki Masuzaki
Apr 22, 2014·Translational Research : the Journal of Laboratory and Clinical Medicine·Ivana V Yang, David A Schwartz
May 27, 2015·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Gabrielle A LockettJohn W Holloway
Feb 12, 2014·Journal of Applied Toxicology : JAT·Valentina BollatiPier Alberto Bertazzi
Dec 5, 2012·Journal of Nucleic Acids·Juan Wang, Qinghua Cui
Jan 19, 2012·International Journal of Epidemiology·Lifang HouAndrea Baccarelli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Jean-François MouilletYoel Sadovsky
© 2021 Meta ULC. All rights reserved