Maternal consumption of green tea extract during pregnancy and lactation alters offspring's metabolism in rats

PloS One
Ana C L HachulLila M Oyama

Abstract

Green tea extract has anti-inflammatory and antioxidant effects which improve dyslipidemia and decrease adipose tissue depots associated with hyperlipidic diet consumption. To evaluate the effect of green tea extract consumption by rats during pregnancy and lactation on the metabolism of their offspring that received control or high-fat diet with water during 10 weeks after weaning. Wistar rats received water (W) or green tea extract diluted in water (G) (400 mg/kg body weight/day), and control diet (10 animals in W and G groups) during pregnancy and lactation. After weaning, offspring received water and a control (CW) or a high-fat diet (HW), for 10 weeks. One week before the end of treatment, oral glucose tolerance test was performed. The animals were euthanized and the samples were collected for biochemical, hormonal and antioxidant enzymes activity analyses. In addition, IL-10, TNF-α, IL-6, and IL-1β were quantified by ELISA while p-NF-κBp50 was analyzed by Western Blotting. Repeated Measures ANOVA, followed by Tukey's test were used to find differences between data (p < 0.05). The consumption of high-fat diet by rats for 10 weeks after weaning promoted hyperglycemia and hyperinsulinemia, and increased fat depots. The inges...Continue Reading

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Citations

Sep 27, 2019·Food Research International·Lívia Beatriz Aparecida Ribeiro SilvaThomas Prates Ong
May 6, 2021·International Journal of Environmental Research and Public Health·Bernardo Gindri Dos SantosCristiane Matté
May 18, 2021·Planta medica·Kasimu Ghandi IbrahimMustapha Umar Imam
Oct 6, 2021·Food & Function·Lei ZhaoZhao-Jia Ge

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Methods Mentioned

BETA
ELISA
electrophoresis
nuclear translocation

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