Maternal Deprivation Enhances Contextual Fear Memory via Epigenetically Programming Second-Hit Stress-Induced Reelin Expression in Adult Rats

The International Journal of Neuropsychopharmacology
Run-Hua WangHu Zhao

Abstract

Early-life stress increases the risk for posttraumatic stress disorder. However, the epigenetic mechanism of early-life stress-induced susceptibility to posttraumatic stress disorder in adulthood remains unclear. Rat pups were exposed to maternal deprivation during postnatal days 1 to 14 for 3 hours daily and treated with the DNA methyltransferase inhibitor zebularine, L-methionine, or vehicle 7 days before contextual fear conditioning, which was used as a second stress and to mimic the reexperiencing symptom of posttraumatic stress disorder in adulthood. Long-term potentiation, dendritic spine density, DNA methyltransferase mRNA, Reelin gene methylation, and Reelin protein expression in the hippocampal CA1 were measured. Maternal deprivation enhanced contextual fear memory in adulthood. Meanwhile, maternal deprivation decreased DNA methyltransferase mRNA and Reelin gene methylation in the hippocampal CA1 on postnatal days 22 and 90. Reelin protein expression was increased in the hippocampal CA1 following contextual fear conditioning in adulthood. Furthermore, compared with rats that experienced maternal deprivation alone, rats also exposed to contextual fear conditioning showed an enhanced induction of hippocampal long-term po...Continue Reading

References

Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Dec 3, 1999·Journal of Neuroendocrinology·P MeerloJ M Koolhaas
Dec 11, 1999·Pharmacology, Biochemistry, and Behavior·J LehmannJ Feldon
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Aug 9, 2002·The Journal of Biological Chemistry·Edwin J WeeberJoachim Herz
Aug 15, 2002·The Journal of Biological Chemistry·Nancy DetichMoshe Szyf
Dec 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·L TremolizzoA Guidotti
May 7, 2003·Neuroscience and Biobehavioral Reviews·Christopher R Pryce, Joram Feldon
Feb 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Chenjian LiBruce S McEwen
Jun 29, 2004·Nature Neuroscience·Ian C G WeaverMichael J Meaney
Jul 27, 2004·The Journal of Biological Chemistry·Jonathan M LevensonJ David Sweatt
Jan 27, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jai Sung NohDennis R Grayson
Jun 15, 2005·Annual Review of Biochemistry·Mary Grace Goll, Timothy H Bestor
Jul 1, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mélanie SinagraPascale Chavis
Nov 25, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ian C G WeaverMoshe Szyf
Dec 27, 2005·Neurobiology of Learning and Memory·Shenfeng QiuEdwin J Weeber
Mar 16, 2007·Neuron·Courtney A Miller, J David Sweatt
Feb 2, 2008·Biochimica Et Biophysica Acta·Jonathan M LevensonEdwin J Weeber
Jun 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ruben P AlvarezChristian Grillon
Oct 17, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Farah D LubinJ David Sweatt
Jan 20, 2009·Biological Psychiatry·Tania L RothJ David Sweatt
May 14, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Charlotte A OomenHarm Krugers
Jul 17, 2010·Behavioural Brain Research·Rosamund F LangstonEmma R Wood
Feb 25, 2011·Nature Neuroscience·Peter PenzesKevin M Woolfrey
Jan 3, 2012·Physiology & Behavior·Esther Nederhof, Mathias V Schmidt
Dec 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Faraz A SultanJ David Sweatt
Jan 29, 2013·Ageing Research Reviews·Alexis M StranahanMarlena Wosiski-Kuhn
May 3, 2013·Nature Reviews. Neuroscience·Stephen MarenIsrael Liberzon
Sep 10, 2013·Child Abuse & Neglect·Sharon Mc Elroy, David Hevey
Dec 18, 2013·Molecular Psychiatry·J D GrayB S McEwen

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