Maternal diabetes alters the development of ductus venosus shunting in the fetus

Acta Obstetricia Et Gynecologica Scandinavica
Agnethe LundJörg Kessler

Abstract

Despite adequate glycemic control, the risks of fetal macrosomia and perinatal complications are increased in diabetic pregnancies. Adjustments of the umbilical venous distribution, including increased ductus venosus shunting, can be important fetal compensatory mechanisms, but the impact of pregestational diabetes on umbilical venous and ductus venosus flow is not known. In this prospective study, 49 women with pregestational diabetes mellitus underwent monthly ultrasound examinations from gestational week 20 to 36. The blood velocity and the mean diameters of the umbilical vein and ductus venosus were used for calculating blood flow volumes. The development of the umbilical venous flow, ductus venosus flow and ductus venosus shunt fraction (% of umbilical venous blood shunted through the ductus venosus) was compared with a reference population, and the effect of HbA1c on the ductus venosus flow was assessed. The umbilical venous flow was larger in pregnancies with pregestational diabetes mellitus than in low-risk pregnancies (p < 0.001) but smaller when normalized for fetal weight (p = 0.036). The distributional pattern of the ductus venosus flow developed differently in diabetic pregnancies, particularly during the third tri...Continue Reading

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Citations

Feb 12, 2019·Acta Obstetricia Et Gynecologica Scandinavica·Enrico FerrazziGanesh Acharya
Dec 15, 2020·The Journal of Clinical Endocrinology and Metabolism·Satoru IkenouePathik D Wadhwa
Aug 10, 2021·Frontiers in Endocrinology·Satoru IkenoueDaigo Ochiai

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