Maternal diet and dioxin-like activity, bulky DNA adducts and micronuclei in mother-newborns

Mutation Research
M PedersenL E Knudsen

Abstract

Maternal diet can contribute to carcinogenic exposures and also modify effects of environmental exposures on maternal and fetal genetic stability. In this study, associations between maternal diet and the levels of dioxin-like plasma activity, bulky DNA adducts in white blood cells and micronuclei (MN) in lymphocytes from mother to newborns were examined. From 98 pregnant women living in the greater area of Copenhagen, Denmark in 2006-2007, maternal peripheral blood and umbilical cord blood were collected, together with information on health, environmental exposure and lifestyle. Maternal diet was estimated on the basis of maternal food frequency questionnaire (FFQ) completed by the end of pregnancy. Biomarkers were detected in paired blood samples through the dioxin-responsive chemical-activated luciferase expression (CALUX)(®) bioassay, (32)P-postlabelling technique and cytokinesis-block MN assay. Maternal preference for meats with dark surface were significantly associated with higher bulky DNA adducts in both maternal (β 95%CI; 0.46 (0.08, 0.84)) and cord blood (β 95%CI; 0.46 (0.05, 0.86)) before and after adjustment for potential confounders. No other significant associations between the 18 dietary variables and the biomar...Continue Reading

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Citations

Jan 15, 2013·International Journal of Hygiene and Environmental Health·Radim J SramHana Votavova
Jun 4, 2013·The Science of the Total Environment·Eleni PapadopoulouManolis Kogevinas
Feb 4, 2014·Epidemiology·Marina VafeiadiUNKNOWN NewGeneris Consortium
Mar 9, 2021·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Laura Pelland-St-PierreVikki Ho

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