Maternal distress and child neuroendocrine and immune regulation

Social Science & Medicine
Jenna L RiisSara B Johnson

Abstract

Neuroendocrine-immune regulation is essential for maintaining health. Early-life adversity may cause dysregulation in the neuroendocrine-immune network through repeated activation of the stress response, thereby increasing disease risk. This paper examined the extent to which maternal psychological well-being moderates neuroendocrine-immune relations in children. We used data from a laboratory-based study of mothers and their five-year old children (n = 125 mother-child pairs) conducted from 2011 to 2013 in Baltimore, Maryland. Child saliva was assayed for markers of immune function (i.e., cytokines: interleukin [IL]-1β, IL-6, IL-8, tumor necrosis factor alpha [TNF-α]) and hypothalamic-pituitary-adrenal activity (i.e., cortisol). A composite score for depressive symptoms, anxiety, and parenting stress characterized maternal psychological distress. Multilevel mixed models examined the relationship between maternal psychological well-being and child neuroendocrine-immune relations. Significant cytokine × maternal distress interactions indicated that as maternal distress increased, expected inverse cytokine-cortisol relations within children became weaker for IL-1β, IL-6, and TNF-α. Sex-stratified models revealed that these intera...Continue Reading

References

Mar 5, 2003·Brain, Behavior, and Immunity·Christopher L Coe, Gabriele R Lubach
Feb 13, 2004·Biological Psychiatry·Sarah L HalliganLynne Murray
May 5, 2004·Psychological Bulletin·Sally S Dickerson, Margaret E Kemeny
May 5, 2005·Psychological Science·Jessica E KierasMary K Rothbart
Nov 18, 2005·Brain, Behavior, and Immunity·Ronit AvitsurJohn F Sheridan
Mar 4, 2006·Biological Psychology·Tie-Yuan ZhangMichael J Meaney
Jun 5, 2007·Journal of Sleep Research·Mona El-SheikhChristine Acebo
Nov 21, 2007·Paediatric and Perinatal Epidemiology·Rosalind J Wright
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Apr 22, 2008·Development and Psychopathology·Lia C H FernaldMegan R Gunnar
Dec 17, 2008·Brain, Behavior, and Immunity·Aric A PratherAnna L Marsland
Jun 2, 2009·Lancet·Peter J Barnes, Ian M Adcock
Jul 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Gregory E MillerMichael S Kobor
Jul 22, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ketan ShankardassKiros Berhane
Sep 8, 2009·Brain, Behavior, and Immunity·Wesley G MoonsShelley E Taylor
Jan 1, 2008·The Open Biomarkers Journal·Zora DjuricChristopher M Masi
Mar 25, 2010·Child Development·Janet A DiPietroJoseph P Pillion
Aug 25, 2010·Physiology & Behavior·Peggy S KellerDouglas A Granger
Nov 6, 2010·Clinical Child and Family Psychology Review·Sherryl H GoodmanDevin Heyward
Aug 6, 2011·Nature Reviews. Immunology·Michael R Irwin, Steven W Cole
Aug 13, 2011·Bulletin of the World Health Organization·Pamela J SurkanMaureen M Black
Sep 6, 2011·Physiology & Behavior·Andrea Danese, Bruce S McEwen
Dec 28, 2011·Pediatrics·Andrew S GarnerUNKNOWN Section on Developmental and Behavioral Pediatrics
Dec 28, 2011·Pediatrics·Jack P ShonkoffUNKNOWN Section on Developmental and Behavioral Pediatrics
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jack P Shonkoff
Jan 23, 2013·Pediatrics·Sara B JohnsonJenna Riis
May 2, 2013·JAMA : the Journal of the American Medical Association·David A Brent, Michael Silverstein
Jul 31, 2013·Psychoneuroendocrinology·Clancy BlairUNKNOWN FLP Investigators
Sep 28, 2013·The Journal of Pediatrics·Frederick B PalmerFrances A Tylavsky
Apr 18, 2014·Annals of the New York Academy of Sciences·Matthew QuinnJohn A Cidlowski
Sep 11, 2014·Brain, Behavior, and Immunity·Danica C SlavishChristopher G Engeland

❮ Previous
Next ❯

Citations

May 27, 2017·Journal of Child and Adolescent Psychiatric Nursing : Official Publication of the Association of Child and Adolescent Psychiatric Nurses, Inc·Lee SmithBattleJoanne K Schneider
Feb 15, 2018·Research in Nursing & Health·Eileen M CondonLinda C Mayes
Aug 12, 2017·Attachment & Human Development·Jeffrey R Measelle, Jennifer C Ablow
Feb 23, 2019·Nursing Research·Eileen M CondonLois S Sadler
Nov 2, 2019·Developmental Psychobiology·Charlotte C EllbergLeah C Hibel
Sep 12, 2019·International Journal of Behavioral Medicine·Jenna L RiisSara B Johnson
Jul 12, 2017·Developmental Psychobiology·Jason DavidJennifer Ablow
Dec 7, 2016·World Journal of Gastroenterology : WJG·Eli Magen, Tinatin Chikovani
Jan 12, 2021·Development and Psychopathology·Brie Reid, Andrea Danese
Mar 3, 2020·Brain, Behavior, and Immunity·Naomi PriestDavid Burgner
Oct 11, 2017·Journal of Affective Disorders·Teresa BuccheriUNKNOWN STRONG Kids Research Team
Nov 21, 2017·Social Science & Medicine·Blair T Johnson, Rebecca L Acabchuk
Apr 21, 2021·Psychoneuroendocrinology·Lindsay HuffhinesHannah M C Schreier

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.