Maternal Exercise Does Not Significantly Alter Adult Rat Offspring Vascular Function

Medicine and Science in Sports and Exercise
A Nicole BlaizeSean Newcomer

Abstract

Research has revealed the role of adverse behaviors during pregnancy on metabolic and cardiovascular health outcomes in offspring. However, minimal attention has been focused on positive prenatal behaviors, such as exercise, and the effect on offspring health outcomes. The objective of this investigation was to test the hypothesis that mothers who voluntarily exercise during pregnancy would improve endothelial function in offspring from exercising compared with sedentary mothers. Female Sprague Dawley rats were divided into sedentary (n = 10) or exercise (n = 9) groups with, the exercise group having voluntary access to a running wheel throughout gestation. Litter characteristics (weight and size) were taken 1 d after birth. After weaning, offspring were placed in sedentary cages where they remained until 4 or 8 months of age. Offspring food consumption and cage activity were assessed during a 72-h interval at 2, 4, 6, and 8 months of age. The abdominal aortas of offspring were harvested at 4 or 8 months of age, and vascular function was assessed using cumulative doses of endothelium-dependent (acetylcholine/10-10 M) and independent (sodium nitroprusside/10-10 M) vasodilators. There were no significant differences in litter siz...Continue Reading

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Citations

Sep 2, 2015·Journal of Hepatology·Ryan D SheldonR Scott Rector
Sep 1, 2016·Journal of Developmental Origins of Health and Disease·C S Rosenfeld
Apr 4, 2017·Acta Physiologica·J Denham
Jul 22, 2015·Exercise and Sport Sciences Reviews·A Nicole BlaizeSean C Newcomer
Dec 2, 2020·Reproductive Sciences·Áine BrislaneNicola D Hopkins
Aug 4, 2021·International Journal of Sports Medicine·Polina M KrassovskaiaNicholas T Broskey
Apr 4, 2017·Gynécologie, Obstétrique, Fertilité & Sénologie·S VerdièreP Deruelle

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