Maternal Exposure to Ambient Particulate Matter ≤2.5 µm During Pregnancy and the Risk for High Blood Pressure in Childhood

Hypertension
Mingyu ZhangXiaobin Wang

Abstract

Exposure to ambient air pollution has been associated with greater risk of elevated blood pressure (BP) in adults and children. Recent evidence suggests that air pollution exposure in pregnancy may also portend increased risk for the next generation; however, few studies have examined this relationship. We conducted a prospective study of 1293 mothers in the Boston Birth Cohort (enrolled 1998-2012) and their children who had follow-up visits between 3 and 9 years of age and complete exposure and outcome data. Our primary exposure, ambient particulate matter ≤2.5 µm (PM2.5) concentration during pregnancy, was estimated by matching mother's residential address to the US Environmental Protection Agency's air quality monitors. We defined our primary outcome child systolic BP (SBP) percentile according to US reference (Fourth Report) and classified elevated BP as SBP ≥90th percentile. Our multivariable-adjusted cubic spline showed a sharp increase in offspring SBP percentile and risk for elevated BP when third-trimester PM2.5 concentration was ≥13 μg/m3 The highest versus lowest tertile of third-trimester PM2.5 exposure was associated with a 4.85 (95% confidence interval: 1.38-8.37) percentile increase in child SBP or a 1.61 (95% co...Continue Reading

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Citations

Apr 30, 2019·Hypertension
Jan 30, 2020·Health Promotion Journal of Australia : Official Journal of Australian Association of Health Promotion Professionals·Gemma Carey
Jul 9, 2020·Hypertension·UNKNOWN Editors
Jul 22, 2019·Current Diabetes Reports·Chris C Lim, George D Thurston
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Apr 2, 2021·Reviews on Environmental Health·Liwei YangLin Ye
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