Maternal exposure to environmentally relevant doses of bisphenol A causes reproductive dysfunction in F1 adult male rats: protective role of melatonin

Environmental Science and Pollution Research International
Samuel Gbadebo OlukoleBankole Olusiji Oke

Abstract

This study investigated the protective effects of melatonin (MLT), a potent antioxidant, in male Wistar rats exposed to environmentally relevant doses of bisphenol A (BPA) in utero. Pregnant Wistar rats were randomly assigned into five groups. Group 1 (control) received 0.2 mL 1% dimethyl sulfoxide (DMSO)/99% canola oil as vehicle; group 2 received BPA at 25 μg/kg/day; group 3 received BPA at 250 μg/kg/day; group 4 received BPA at 25 μg/kg/day with concurrent MLT 1 mg/kg/day while group 5 received BPA at 250 μg/kg/day with concurrent MLT 1 mg/kg/day. Treatments were by gavage from gestational day (GD) 10-21. The BPA-treated rats showed dose-dependent significant reduction in body weight, gonosomatic index, sperm motility, livability and count. Also, BPA caused significant reduction in the levels of serum testosterone and luteinizing hormone while it caused significant increases in the levels of follicle stimulating hormone as well as estradiol. Furthermore, BPA induced testicular oxidative stress including significant decreases in the activities of testicular SOD, GSH and GPx as well as GST, increasing the levels of testicular MDA and H2O2. It further induced interstitial necrosis and germinal cell degeneration in the testis wi...Continue Reading

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Jan 8, 2019·Environmental Science and Pollution Research International·Samuel Gbadebo OlukoleBankole Olusiji Oke

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Citations

Jan 16, 2021·Environmental Science and Pollution Research International·Katarzyna SzkudelskaTomasz Szkudelski
Jan 15, 2021·Antioxidants·Rosanna Chianese, Riccardo Pierantoni
Mar 7, 2021·Antioxidants·Joana SantiagoMargarida Fardilha

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