Maternal exposure to exogenous nitrogen compounds and complications of pregnancy

Archives of Environmental Health
S TabacovaR E Little

Abstract

Increased lipid peroxidation and reduced antioxidant activity have been reported with pregnancy complications. Given that exogenous oxidants stimulate formation of lipid peroxides, the authors investigated the relationship between exposure to nitrogen-oxidizing species and pregnancy complications and took into account markers of antioxidant and oxidant status. The study sample included pregnant women who were from an area polluted by oxidized nitrogen compounds. Methemoglobin, a biomarker of individual exposure, was determined, as were measures of oxidant/antioxidant status, including glutathione balance and lipid peroxide levels. Only 10 women experienced normal pregnancies. The most common complications were anemia (67%), threatened abortion/premature labor (33%), and signs of preeclampsia (23%). Methemoglobin was elevated significantly in all three conditions, compared with normal pregnancies. Reduced:total glutathione decreased, whereas lipid peroxide levels increased. These results suggest that maternal exposure to environmental oxidants can increase the risk of pregnancy complications through stimulation of the formation of cell-damaging lipid peroxides and from a decrease in maternal antioxidant reserves.

References

Jan 9, 1971·Lancet·D A Mossel
Mar 1, 1968·Electroencephalography and Clinical Neurophysiology·D T Cody
Jul 1, 1984·British Journal of Obstetrics and Gynaecology·J D GoodmanG S Dawes
Dec 1, 1993·American Journal of Obstetrics and Gynecology·S W Walsh, Y Wang

❮ Previous
Next ❯

Citations

Nov 24, 1999·Reproductive Toxicology·R E Little, B C Gladen
Nov 14, 1998·Archives of Environmental Health·S TabacovaL Balabaeva
Feb 2, 2010·Environmental Health : a Global Access Science Source·Ferran BallesterMarisa Rebagliato
Oct 16, 2010·Environmental Health : a Global Access Science Source·Deana M ManassaramCarolyn P Monteilh
Aug 3, 2002·Environmental Health Perspectives·Catherine L ZemanMarianna Vlad
Dec 4, 2003·Environmental Health Perspectives·Lucijan Mohorovic
Mar 2, 2006·Environmental Health Perspectives·Deana M ManassaramDeborah M Moll
Feb 15, 2011·International Journal of Environmental Research and Public Health·Lucijan MohorovicVladimir Micovic
May 1, 2004·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Thelma E PatrickJames M Roberts
Sep 15, 2009·Biological Psychiatry·Bung-Nyun KimYun-Chul Hong
Jan 19, 2010·Paediatric and Perinatal Epidemiology·Carole B RudraJianbo Yu
Nov 23, 2006·Medical Hypotheses·Lucijan Mohorovic
May 20, 2011·International Journal of Occupational Medicine and Environmental Health·Joanna Jurewicz, Wojciech Hanke
Dec 18, 2007·Mitochondrion·Digna R VelezScott M Williams
May 2, 2016·BMC Pharmacology & Toxicology·Jess JaroszWade A Grow
Apr 17, 2009·Journal of the American Chemical Society·Weston L DanielChad A Mirkin
Oct 12, 2016·Cell and Tissue Research·Mariana Matera VerasPaulo Saldiva
Aug 8, 2007·Ciência & saúde coletiva·Deana M ManassaramDeborah M Moll

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.