Maternal exposure to farming environment protects offspring against allergic diseases by modulating the neonatal TLR-Tregs-Th axis

Clinical and Translational Allergy
Jinyan YuJing Liu

Abstract

As the development of urbanization in China, the morbidity of allergic disease rise up prominently even in children, which may be partially associated with the excessively clean environment. It has been reported that common microorganism in rural environment shows protective effects on allergic disease by modulating TLRs-Tregs/Th cell axis. But the mechanism of this protection still needs to be elucidated in detail. We investigated the effects of maternal exposure to farming environment on the neonatal innate immune system, especially on the TLR-Treg-Th (Th1, Th2, Th9, and Th17) axis, in the Jilin province of China. Eighty-four non-farming and 42 farming pregnant women were recruited. Endotoxins and glucans in dust from the living rooms of the pregnant mothers were measured. Cord blood mononuclear cells were challenged with phytohemagglutinin, lipopolysaccharide, or peptidoglycan. Proliferative response of lymphocyte was measured by 3H-TdR incorporation methods, CD4 + CD25 + FOXP3 + T cells percentage was assessed with flow cytometry, Tregs specific genes (FOXP3, LAG3, GITR, CTLA-4 and TGF-β) and TLR2, TLR4 genes expression were detected by RT-PCR, specific cytokines of Th1, Th2, Th9, Th17 and Tregs were measured with flow cyto...Continue Reading

References

Jun 3, 2000·Nature Genetics·N C ArbourD A Schwartz
Sep 21, 2002·Lancet·Roger P LauenerUNKNOWN ALEX study group
Mar 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Chunming Ding, Charles R Cantor
Mar 10, 2004·The Journal of Allergy and Clinical Immunology·Waltraud EderUNKNOWN ALEX Study Team
Mar 15, 2005·American Journal of Respiratory and Critical Care Medicine·Michael S D KormannMichael Kabesch
Apr 25, 2006·The Journal of Allergy and Clinical Immunology·Markus Johannes EgeUNKNOWN Parsifal Study team
Jul 15, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D RastogiR L Miller
Feb 24, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marilyn HalonenAnne L Wright
Jan 29, 2011·Current Allergy and Asthma Reports·Marek Jutel, Cezmi A Akdis
Feb 25, 2011·The New England Journal of Medicine·Markus J EgeUNKNOWN GABRIELA Transregio 22 Study Group
Jul 30, 2011·Trends in Immunology·Deborah H Strickland, Patrick G Holt
Jan 20, 2012·Journal of Inflammation Research·Agnes HamzaouiKamel Hamzaoui
Feb 23, 2012·PloS One·Karin SahlanderLena Palmberg
Nov 28, 2013·The Journal of Allergy and Clinical Immunology·Anna LluisBianca Schaub
Dec 3, 2014·The Journal of Allergy and Clinical Immunology·Georg LossUNKNOWN PASTURE study group
Mar 18, 2015·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Gareth MarlowAngharad R Morgan
Dec 18, 2015·European Clinical Respiratory Journal·Simon F Thomsen
Aug 16, 2016·The New England Journal of Medicine·Michelle M SteinAnne I Sperling
Dec 16, 2016·Annals of the American Thoracic Society·Megan Ulmer CarnesStephanie J London

❮ Previous
Next ❯

Citations

May 24, 2019·Clinical and Experimental Immunology·D D Nyangahu, H B Jaspan
Oct 19, 2019·Experimental Physiology·Fiona B McDonaldKen D O'Halloran
Dec 14, 2019·Clinical and Translational Allergy·C A AkdisM Jutel
Apr 25, 2020·Frontiers in Immunology·Elze Rackaityte, Joanna Halkias
Jun 17, 2020·Journal of Developmental Origins of Health and Disease·Delicia Shu-Qin OoiEvelyn Xiu-Ling Loo
Jul 27, 2021·The Journal of Allergy and Clinical Immunology·Yuan GaoPeter Vuillermin

❮ Previous
Next ❯

Methods Mentioned

BETA
density-gradient centrifugation
flow cytometry
PCR
genotyping

Software Mentioned

Spectrodesigner
Primer Express
Primer5

Related Concepts

Related Feeds

Bacterial Cell Wall Structure (ASM)

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Bacterial Cell Wall Structure

Bacterial cell walls are made of peptidoglycan (also called murein), which is made from polysaccharide chains cross-linked by unusual peptides containing D-amino acids. Here is the latest research on bacterial cell wall structures.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.