PMID: 15226600Jul 1, 2004Paper

Maternal exposure to low doses of bisphenol a has no effects on development of female reproductive tract and uterine carcinogenesis in Donryu rats

The Journal of Reproduction and Development
Midori YoshidaAkihiko Maekawa

Abstract

Effects of maternal exposure to low doses of bisphenol A (BPA), including those comparable with human exposure levels, on growth and development of the female reproductive system and uterine carcinogenesis in Donryu rats were investigated. Dams were administered BPA (0, 0.006 and 6 mg/kg/day) daily by gavage from gestation day 2 up to the day before weaning (postnatal day 21 at offspring). The serum levels of BPA were significantly elevated in the dams receiving 6 mg/kg/day, however, BPA levels in the milk of dams, and those in the serum and liver of offspring were similar between control and treated groups. The treatment did not exert any influences on uterine development including weight, gland genesis and estrogen receptor alpha expression, vaginal opening and gonadotropin secretion in the female offspring up to puberty. After maturation, no effects were evident with regard to estrous cyclicity in female offspring treated with BPA. In addition, the treatment had no effects on age-related morphological changes of the reproductive and endocrine organs and uterine carcinogenesis until 15 months of age. The results demonstrate that maternal exposure to BPA at levels comparable to human exposure did not have any effects on the fe...Continue Reading

References

Jan 15, 1976·American Journal of Obstetrics and Gynecology·G P Wood, R C Boronow
Jul 1, 1990·The Journal of Endocrinology·G WatanabeS Sasamoto
Jan 1, 1990·Journal of Cancer Research and Clinical Oncology·T NagaokaA Maekawa
Nov 1, 1989·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R E MorrisseyJ J Heindel
Nov 1, 1985·Endocrinology·W S BranhamE Ridlon
Mar 20, 1981·Science·N J MacLusky, F Naftolin
Jun 15, 1993·Microscopy Research and Technique·J S Noumoff, S Faruqi
Nov 3, 1998·Environmental Health Perspectives·J Ashby, H Tinwell
Mar 30, 1999·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J Donnez
Aug 13, 1999·Toxicological Sciences : an Official Journal of the Society of Toxicology·S Z CagenL R Harris
Oct 28, 1999·Regulatory Toxicology and Pharmacology : RTP·S Z CagenL R Harris
Nov 5, 1999·Nature·K L HowdeshellF S vom Saal
Apr 4, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·L H PottengerJ M Waechter
May 29, 2000·Reproductive Toxicology·S KatsudaA Maekawa
Jun 1, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·S KwonF Welsch
Jul 27, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·A D PapaconstantinouK M Brown
Oct 24, 2000·Toxicology and Applied Pharmacology·R W SnyderT R Fennell
Jun 1, 2001·Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan·Y KawamuraT Maitani
Jun 21, 2002·Toxicological Sciences : an Official Journal of the Society of Toxicology·R W TylJ M Waechter
Oct 19, 1962·Science·N TAKASUGIK B DEOME

❮ Previous
Next ❯

Citations

Dec 11, 2013·The Journal of Endocrinology·Emily PanagiotidouEfthymia Kitraki
Aug 28, 2012·Epigenomics·Keith E LathamNora Engel
Jan 12, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Calvin C WillhiteClifton J McLellan
Oct 24, 2015·Reproductive Toxicology·Darcie D SeachristRuth A Keri
Jun 26, 2008·Reproductive Toxicology·Young Joo LeeHae-Seong Yoon
Aug 9, 2007·Reproductive Toxicology·Catherine A RichterFrederick S vom Saal
Aug 21, 2007·Reproductive Toxicology·Ruth A KeriGail S Prins
Jul 10, 2008·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Robert E ChapinSusan R Woskie
Nov 22, 2005·Life Sciences·Masaru FuruyaYasuhiro Tsukamoto
Aug 19, 2007·Toxicology and Applied Pharmacology·Yuko KawamotoShinsuke Morisawa
Apr 6, 2017·Regulatory Toxicology and Pharmacology : RTP·Julie E GoodmanSara Pacheco Shubin
Sep 7, 2006·Critical Reviews in Toxicology·Julie E GoodmanLorenz R Rhomberg
Aug 30, 2018·Journal of Developmental Origins of Health and Disease·M DesaiM G Ross
Jan 29, 2019·Reproduction : the Official Journal of the Society for the Study of Fertility·Hannah Mathew, Shruthi Mahalingaiah
Aug 1, 2019·Toxicology and Industrial Health·Özay GüleşÜlker Eren

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.