Maternal factor-mediated epigenetic gene silencing in the ascidian Ciona intestinalis.

Molecular Genetics and Genomics : MGG
Yasunori SasakuraNori Satoh

Abstract

Epigenetic regulation of genes plays a critical role in achieving proper gene expression during development, and it has been reported that epigenetic modifications are associated with transposon silencing in many organisms. Here, we report a type of epigenetic gene silencing, maternal gfp/gene silencing (MGS), in the basal chordate Ciona intestinalis. A transgenic line of Ciona, Tg[MiTFr3dTPOG]45 (abbreviated as Tg45), which was created with the Minos transposon, has a tandemly arrayed insertion of gfp in the promoter region of Ci-CesA. Progeny of Tg45 showed a reduced level of GFP expression when eggs of Tg45 were fertilized with sperm of other gfp transgenic lines. Although the genotype is the same, animals developed from Tg45 sperm and the eggs of other transgenic lines did not exhibit this phenomenon, suggesting the involvement of a maternal cytoplasmic factor that influences GFP expression. The silencing starts during oogenesis and continues after fertilization without any tissue specificity. We found that post-transcriptional degradation of the gfp mRNA is involved in MGS.

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Citations

May 30, 2012·Development, Growth & Differentiation·Narudo KawaiYasunori Sasakura
Aug 8, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Akiko HozumiYasunori Sasakura
Sep 13, 2014·Development, Growth & Differentiation·Haruka SasakiYasunori Sasakura
Aug 19, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Chisato KamiyaYasunori Sasakura
Apr 19, 2015·Developmental Biology·Narudo KawaiYasunori Sasakura
Nov 28, 2013·Epigenetics & Chromatin·Miho M SuzukiAtsuo Nakayama
Mar 30, 2020·Current Biology : CB·Akiko HozumiYasunori Sasakura
Nov 5, 2019·Developmental Biology·Yukako TajimaYasunori Sasakura
Oct 23, 2014·Development·Alberto StolfiLionel Christiaen
Aug 19, 2021·Developmental Biology·Haley M SmithWilliam C Smith
Nov 14, 2021·Nature Communications·Kushal KolarMarios Chatzigeorgiou

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