Maternal fish oil supplementation in lactation: effect on visual acuity and n-3 fatty acid content of infant erythrocytes

Lipids
Lotte LauritzenKim F Michaelsen

Abstract

Studies on formula-fed infants indicate a beneficial effect of dietary DHA on visual acuity. Cross-sectional studies have shown an association between breast-milk DHA levels and visual acuity in breast-fed infants. The objective in this study was to evaluate the biochemical and functional effects of fish oil (FO) supplements in lactating mothers. In this double-blinded randomized trial, Danish mothers with habitual fish intake below the 50th percentile of the Danish National Birth Cohort were randomized to microencapsulated FO [1.3 g/d long-chain n-3 FA (n-3 LCPUFA)] or olive oil (OO). The intervention started within a week after delivery and lasted 4 mon. Mothers with habitual high fish intake and their infants were included as a reference group. Ninety-seven infants completed the trial (44 OO-group, 53 FO-group) and 47 reference infants were followed up. The primary outcome measures were: DHA content of milk samples (0, 2, and 4 mon postnatal) and of infant red blood cell (RBC) membranes (4 mon postnatal), and infant visual acuity (measured by swept visual evoked potential at 2 and 4 mon of age). FO supplementation gave rise to a threefold increase in the DHA content of the 4-mon milk samples (P < 0.001). DHA in infant RBC re...Continue Reading

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Citations

Aug 11, 2007·The British Journal of Nutrition·Berthold KoletzkoUNKNOWN International Society for the Study of Fatty Acids and Lipids
Jul 9, 2011·The British Journal of Nutrition·Lotte LauritzenKim F Michaelsen
May 25, 2012·The British Journal of Nutrition·Cristina CampoyRicardo Uauy
Jul 28, 2006·The British Journal of Nutrition·John H Langdon
Aug 15, 2009·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·E DewaillyP Julien
Feb 16, 2005·Current Opinion in Gastroenterology·Karen C McCowen, Bruce R Bistrian
Jul 12, 2005·Pediatric Research·Lotte LauritzenKim F Michaelsen
Jan 11, 2008·Journal of Perinatal Medicine·Berthold KoletzkoUNKNOWN World Association of Perinatal Medicine Dietary Guidelines Working Group
Jan 31, 2012·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Lefkothea Stella KremmydaAles Zak
Aug 2, 2008·Journal of Pediatric Gastroenterology and Nutrition·J Belkind-GersonM S Parra-Cabrera
Aug 26, 2011·Journal of Pediatric Gastroenterology and Nutrition·Anders Daniel AndersenLotte Lauritzen
Jan 12, 2016·Current Opinion in Clinical Nutrition and Metabolic Care·Kristina Harris Jackson, William S Harris
Feb 6, 2016·Lipids·Michelle L BaackWilliam S Harris
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Mar 5, 2011·Maternal & Child Nutrition·Lotte Lauritzen, Susan E Carlson
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