Maternal folate status in early pregnancy and child emotional and behavioral problems: the Generation R Study

The American Journal of Clinical Nutrition
Jolien Steenweg-de GraaffHenning Tiemeier

Abstract

Maternal prenatal folate status has been linked to neurodevelopmental disorders, but the association with child emotional and behavioral problems is unclear. We assessed the association of maternal folate status during pregnancy with child emotional and behavioral problems. Also, we examined whether any association between folate status and child problems is a consequence of maternal folic acid supplement use or variation in maternal MTHFR genotype. Within a population-based cohort, we measured maternal plasma folate concentrations in early pregnancy and assessed folic acid supplement use by questionnaire. Mothers of European descent were genotyped for the MTHFR 677 C→T polymorphism. Child emotional and behavioral problems were assessed with the Child Behavior Checklist at 3 y in 3209 children. Children of mothers with prenatal folate deficiency were at higher risk of emotional problems (OR: 1.57; 95% CI: 1.03, 2.38) but not behavioral problems (OR: 1.00; 95% CI: 0.64, 1.56) after adjustment for confounders. A higher risk of emotional problems was also found in children whose mothers started using folic acid supplements late or did not use supplements at all (OR: 1.45; 95% CI: 1.14, 1.84) than in children whose mothers started ...Continue Reading

References

Dec 24, 1992·The New England Journal of Medicine·A E Czeizel, I Dudás
Dec 1, 1994·Metabolism: Clinical and Experimental·R P Steegers-TheunissenT K Eskes
Apr 16, 1999·The Journal of Nutrition·L B Bailey, J F Gregory
Jun 25, 2002·Preventive Medicine·H E K de WalleL T W de Jong-van den Berg
Jun 6, 2003·Best Practice & Research. Clinical Obstetrics & Gynaecology·William Martin Hague
Oct 16, 2003·JAMA : the Journal of the American Medical Association·E Jane CostelloAdrian Angold
Apr 13, 2004·International Journal of Epidemiology·George Davey Smith, Shah Ebrahim
Nov 3, 2004·Akusherstvo i ginekologii︠a︡·V StoĭkovaA Tsoncheva
Jul 11, 2006·European Journal of Epidemiology·Vincent W V JaddoeAlbert Hofman
Aug 23, 2006·Nature Reviews. Neuroscience·Henk J BlomRichard H Finnell
Nov 10, 2006·The American Journal of Clinical Nutrition·Roy M NilsenPer M Ueland
Jun 8, 2007·Maternal and Child Health Journal·George L Wehby, Jeffrey C Murray
Dec 21, 2007·European Journal of Epidemiology·Vincent W V JaddoeAlbert Hofman
Jan 31, 2009·Nutritional Neuroscience·Constanza del Río GarciaLizbeth López-Carrillo
Feb 25, 2009·Birth Defects Research. Part A, Clinical and Molecular Teratology·Anne M MolloyPeadar N Kirke
Aug 14, 2009·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Alina Rodriguez
Sep 8, 2009·The Journal of Nutritional Biochemistry·Kyong-chol KimSang-Woon Choi
Sep 24, 2009·The British Journal of Nutrition·Sabine J RozaHenning Tiemeier
Oct 31, 2009·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Wolff SchlotzKeith M Godfrey
Dec 8, 2009·European Journal of Epidemiology·Stefan Walter, Henning Tiemeier
Dec 9, 2009·The British Journal of Nutrition·Betina H ThuesenAllan Linneberg
Apr 9, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Joe Leigh SimpsonWolfgang Holzgreve
Apr 27, 2010·Annual Review of Nutrition·Graham C Burdge, Karen A Lillycrop
May 28, 2010·The American Journal of Clinical Nutrition·J Richard PilsnerMauricio Hernández-Avila
Jul 20, 2010·Journal of Affective Disorders·Rolieke A M CentsMijke P Lambregtse-van den Berg
Oct 23, 2010·European Journal of Epidemiology·Vincent W V JaddoeAlbert Hofman
May 26, 2011·Epidemiology·Rebecca J SchmidtIrva Hertz-Picciotto

❮ Previous
Next ❯

Citations

Jul 26, 2013·European Journal of Nutrition·Tania AnjosUNKNOWN NUTRIMENTHE Research Group
Apr 9, 2014·Journal of Autism and Developmental Disorders·Joseph M BraunBruce P Lanphear
Oct 23, 2012·European Journal of Epidemiology·Vincent W V JaddoeAlbert Hofman
Nov 5, 2013·Public Health Nutrition·Se-Young OhJiyoung V Oh
Oct 30, 2012·Journal of the American Academy of Child and Adolescent Psychiatry·Henning TiemeierFrank C Verhulst
Aug 15, 2013·Annals of Neurology·Gustavo C RománHenning Tiemeier
Jul 17, 2015·Birth Defects Research. Part A, Clinical and Molecular Teratology·Rima ObeidSimon Wieser
Aug 6, 2015·The British Journal of Nutrition·Elizabeth A DeVilbissBrian K Lee
Aug 3, 2014·European Journal of Public Health·Jolien Steenweg-de GraaffSabine J Roza
May 31, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Cathrine HoyoSusan K Murphy
Apr 2, 2013·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Jolien Steenweg-de GraaffSabine J Roza
Feb 8, 2014·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Rima ObeidKlaus Pietrzik
Nov 6, 2014·The Proceedings of the Nutrition Society·C McGarelH McNulty
Dec 21, 2014·European Journal of Epidemiology·Claudia J KruithofVincent W V Jaddoe
Jun 21, 2016·Epigenomics·Rachelle E IrwinColum P Walsh
Jul 21, 2016·Obstetrical & Gynecological Survey·Richard I LowensohnChristie Naze
Jan 16, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Yohei IshikawaMitsuyoshi Urashima
Jul 30, 2015·BMC Public Health·Caren I LantingJacobus P van Wouwe
Jul 10, 2014·Nutrition and Health·Claire Horton
Feb 23, 2018·Acta Paediatrica·Lesley-Anne HenryDiane Lees-Murdock
Dec 15, 2015·The Cochrane Database of Systematic Reviews·Luz Maria De-RegilPura Rayco-Solon
Mar 1, 2020·Journal of Neuroscience Research·Hiba Al RubayeNafisa M Jadavji
Apr 1, 2015·Journal of Perinatal Medicine·Rima ObeidBerthold Koletzko
Aug 12, 2020·Paediatric and Perinatal Epidemiology·Elizabeth W DiemerSonja A Swanson
Jun 2, 2017·International Journal of Genomics·Nguyen Quoc Vuong Tran, Kunio Miyake
Jan 29, 2019·Environmental Health Perspectives·Todd A JuskoMatthew P Longnecker
Jul 28, 2020·Environmental Health Perspectives·Michiel A van den DriesAnjoeka Pronk
May 17, 2019·Advances in Nutrition·Eva F G NaninckElske M Brouwer-Brolsma
Jun 4, 2018·Child Psychiatry and Human Development·Stephanie D'SouzaSusan M B Morton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.