Maternal folic acid supplementation to dams on marginal protein level alters brain fatty acid levels of their adult offspring

Metabolism: Clinical and Experimental
Shobha RaoS P Mahadik

Abstract

Studies on fetal programming of adult diseases have highlighted the importance of maternal nutrition during pregnancy. Folic acid and long-chain essential polyunsaturated fatty acids (LC-PUFAs) have independent effects on fetal growth. However, folic acid effects may also involve alteration of LC-PUFA metabolism. Because marginal deficiency of LC-PUFAs during critical periods of brain growth and development is associated with risks for adult diseases, it is highly relevant to investigate how maternal supplementation of such nutrients can alter brain fatty acid levels. We examined the impact of folic acid supplementation, conventionally used in maternal intervention, on brain essential fatty acid levels and plasma corticosterone concentrations in adult offspring at 11 months of age. Pregnant female rats from 4 groups (6 in each) were fed with casein diets either with 18 g protein/100 g diet (control diet) or treatment diets that were marginal in protein (MP), such as 12 g protein/100 g diet supplemented with 8 mg folic acid (FAS/MP), 12 g protein/100 g diet without folic acid (FAD/MP), or 12 g protein/100 g diet (MP) with 2 mg folic acid. Pups were weaned to a standard laboratory diet with 18 g protein/100 g diet. All male adult...Continue Reading

References

Jun 1, 1975·American Journal of Obstetrics and Gynecology·L Iyengar, K Rajalakshmi
Aug 1, 1972·The Journal of Clinical Endocrinology and Metabolism·H J RuderM B Lipsett
Apr 1, 1996·The Journal of Nutrition·C Wagner
Oct 1, 1996·The British Journal of Nutrition·M DesaiC N Hales
Oct 1, 1996·The British Journal of Nutrition·A LucasC N Hales
Jan 12, 1999·British Journal of Obstetrics and Gynaecology·N SattarI A Greer
May 9, 2000·The American Journal of Clinical Nutrition·T O Scholl, W G Johnson
May 9, 2000·The American Journal of Clinical Nutrition·K M Godfrey, D J Barker
May 6, 2003·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Marianne Haag
May 31, 2003·Stress : the International Journal on the Biology of Stress·T TraustadóttirK S Matt
Oct 2, 2003·The Journal of Nutrition·Sadhana JoshiRamesh Bhonde
Sep 24, 2004·Obstetrical & Gynecological Survey·Pia Saldeen, Tom Saldeen

❮ Previous
Next ❯

Citations

Sep 18, 2012·Best Practice & Research. Clinical Endocrinology & Metabolism·Manuel S Santos, Jaap A Joles
Jan 4, 2007·Seminars in Fetal & Neonatal Medicine·Liza H Kunz, Janet C King
May 26, 2011·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Madhavi Dhobale, Sadhana Joshi
Apr 15, 2011·Metabolism: Clinical and Experimental·Kamini D DangatSadhana R Joshi
May 24, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Gisele Aparecida Dionísio LopesMaria Aparecida Marchesan Rodrigues
Feb 3, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Chantal C HoppeKaren M Moritz
Mar 11, 2008·The American Journal of Clinical Nutrition·A David SmithHelga Refsum

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.