Maternal fructose-intake-induced renal programming in adult male offspring

The Journal of Nutritional Biochemistry
You-Lin TainJulie Y H Chan

Abstract

Nutrition in pregnancy can elicit long-term effects on the health of offspring. Although fructose consumption has increased globally and is linked to metabolic syndrome, little is known about the long-term effects of maternal high-fructose (HF) exposure during gestation and lactation, especially on renal programming. We examined potential key genes and pathways that are associated with HF-induced renal programming using whole-genome RNA next-generation sequencing (NGS) to quantify the abundance of RNA transcripts in kidneys from 1-day-, 3-week-, and 3-month-old male offspring. Pregnant Sprague-Dawley rats received regular chow or chow supplemented with HF (60% diet by weight) during the entire period of pregnancy and lactation. Male offspring exhibited programmed hypertension at 3 months of age. Maternal HF intake modified over 200 renal transcripts from nephrogenesis stage to adulthood. We observed that 20 differentially expressed genes identified in 1-day-old kidney are related to regulation of blood pressure. Among them, Hmox1, Bdkrb2, Adra2b, Ptgs2, Col1a2 and Tbxa2r are associated with endothelium-derived hyperpolarizing factor (EDHF). NGS also identified genes in arachidonic acid metabolism (Cyp2c23, Hpgds, Ptgds and Ptge...Continue Reading

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Citations

Dec 30, 2015·International Journal of Molecular Sciences·You-Lin Tain, Jaap A Joles
Dec 30, 2015·International Journal of Molecular Sciences·You-Lin TainJulie Y H Chan
Aug 8, 2015·International Journal of Molecular Sciences·You-Lin TainLi-Tung Huang
Nov 27, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Y-L TainJ Chan
Oct 13, 2016·The Journal of Nutritional Biochemistry·You-Lin TainJulie Y H Chan
Feb 18, 2017·International Journal of Molecular Sciences·You-Lin Tain, Chien-Ning Hsu
Apr 20, 2017·International Journal of Molecular Sciences·You-Lin Tain, Chien-Ning Hsu
Jun 24, 2016·Food & Function·M Luisa OjedaOlimpia Carreras
Feb 15, 2020·International Journal of Molecular Sciences·Verónica Guarner-LansIsrael Pérez-Torres
Jul 18, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hiroya YamadaShuji Hashimoto
Jun 11, 2020·Journal of Developmental Origins of Health and Disease·Francisca A Tobar-BernalLucía Quevedo-Corona
Oct 28, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Larysa B BondarenkoValentina M Kovalenko
Apr 29, 2020·Food & Function·María Luisa OjedaOlimpia Carreras
Feb 16, 2019·International Journal of Molecular Sciences·Chien-Ning Hsu, You-Lin Tain
Mar 15, 2018·Frontiers in Pediatrics·Eva NüskenKai-Dietrich Nüsken
Mar 7, 2021·International Journal of Molecular Sciences·Chien-Ning Hsu, You-Lin Tain
Jun 3, 2021·Biomedicines·Chien-Ning Hsu, You-Lin Tain

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