Maternal fructose intake induces insulin resistance and oxidative stress in male, but not female, offspring

Journal of Nutrition and Metabolism
Lourdes RodríguezCarlos Bocos

Abstract

Objective. Fructose intake from added sugars correlates with the epidemic rise in metabolic syndrome and cardiovascular diseases. However, consumption of beverages containing fructose is allowed during gestation. Recently, we found that an intake of fructose (10% wt/vol) throughout gestation produces an impaired fetal leptin signalling. Therefore, we have investigated whether maternal fructose intake produces subsequent changes in their progeny. Methods. Blood samples from fed and 24 h fasted female and male 90-day-old rats born from fructose-fed, glucose-fed, or control mothers were used. Results. After fasting, HOMA-IR and ISI (estimates of insulin sensitivity) were worse in male descendents from fructose-fed mothers in comparison to the other two groups, and these findings were also accompanied by a higher leptinemia. Interestingly, plasma AOPP and uricemia (oxidative stress markers) were augmented in male rats from fructose-fed mothers compared to the animals from control or glucose-fed mothers. In contrast, female rats did not show any differences in leptinemia between the three groups. Further, insulin sensitivity was significantly improved in fasted female rats from carbohydrate-fed mothers. In addition, plasma AOPP leve...Continue Reading

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Citations

Aug 19, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Marcella L PortoMarcelo P Baldo
May 5, 2016·The Journal of Nutritional Biochemistry·Lourdes RodríguezCarlos Bocos
Jun 24, 2016·Food & Function·M Luisa OjedaOlimpia Carreras
Jul 1, 2016·Biological Trace Element Research·Salam ZeinIsabelle Hininger-Favier
Aug 23, 2016·Molecular Nutrition & Food Research·Silvia RodrigoCarlos Bocos
Jun 11, 2020·Journal of Developmental Origins of Health and Disease·Francisca A Tobar-BernalLucía Quevedo-Corona
Dec 29, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Mina Kim, Inkyeom Kim
Dec 15, 2020·Clínica e investigación en arteriosclerosis : publicación oficial de la Sociedad Española de Arteriosclerosis·Elena FausteCarlos Bocos

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Methods Mentioned

BETA
ELISA
MDA
glycosylation

Software Mentioned

SSPS

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