PMID: 9538161May 9, 1998Paper

Maternal genistein exposure mimics the effects of estrogen on mammary gland development in female mouse offspring

Oncology Reports
Leena Hilakivi-ClarkeR Clarke

Abstract

Human and animal data indicate that a high maternal estrogen exposure during pregnancy increases breast cancer risk among daughters. This may reflect an increase in the epithelial structures that are the sites for malignant transformation, i.e., terminal end buds (TEBs), and a reduction in epithelial differentiation in the mammary gland. Some phytoestrogens, such as genistein which is a major component in soy-based foods, and zearalenone, a mycotoxin found in agricultural products, have estrogenic effects on the reproductive system, breast and brain. The present study examined whether in utero exposure to genistein or zearalenone influences mammary gland development. Pregnant mice were injected daily with i) 20 ng estradiol (E2); ii) 20 microg genistein; iii) 2 microg zearalenone; iv) 2 microg tamoxifen (TAM), a partial estrogen receptor agonist; or v) oil-vehicle between days 15 and 20 of gestation. E2, genistein, zearalenone, and tamoxifen all increased the density of TEBs in the mammary glands. Genistein reduced, and zearalenone increased, epithelial differentiation. Zearalenone also increased epithelial density, when compared with the vehicle-controls. None of the treatments had permanent effects on circulating E2 levels. M...Continue Reading

Citations

Mar 17, 2006·Breast Cancer Research and Treatment·Kristen S KulpL Michelle Bennett
Jun 29, 2011·Breast Cancer Research and Treatment·Anna H WuChiu-Chen Tseng
Jul 9, 2004·Toxicology and Applied Pharmacology·Kimberly P MillerJodi A Flaws
Jan 5, 2002·Biochemical Pharmacology·P B Hoyer
Sep 29, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Barkha P Patel, Mazen J Hamadeh
Sep 24, 2009·Molecular Nutrition & Food Research·Alicja MortensenGerhard Sontag
Sep 29, 2011·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Gail McCarverKatie Turner
Oct 19, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Abdellah ZinedineJordi Mañes
Jul 2, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K M FlynnS A Ferguson
Dec 30, 2014·Reproductive Toxicology·Daniela A ParodiMary Beth Martin
Aug 6, 2014·Reproductive Toxicology·Gwendolyn OsborneMegan Schwarzman
Oct 7, 2011·The Science of the Total Environment·Elisa V BanderaHelmut Zarbl
Apr 17, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·R Michael McClainJochen Bausch
Sep 12, 2017·International Journal of Molecular Sciences·Daniela A ParodiMary Beth Martin
Jun 8, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anni R ThomsenVibeke M Breinholt
Sep 21, 2006·Journal of the National Cancer Institute·Mark MessinaJohanna W Lampe
Oct 25, 2003·Oncogene·Robert ClarkeLeena A Hilakivi-Clarke

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